The lateral septum and anterior hypothalamus act in tandem to regulate burying in the shock-probe test but not open-arm avoidance in the elevated plus-maze
| Autor: | Steven J. Lamontagne, Mary C. Olmstead, Janet L. Menard |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Agonist medicine.medical_specialty Elevated plus maze medicine.drug_class Maze learning Anxiety Developmental psychology 03 medical and health sciences Behavioral Neuroscience chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Animals Rats Long-Evans 0501 psychology and cognitive sciences 050102 behavioral science & comparative psychology Maze Learning GABA Agonists health care economics and organizations Behavior Animal Muscimol GABAA receptor 05 social sciences Gaba agonists Endocrinology Hypothalamus Anterior nervous system chemistry Hypothalamic Area Lateral Shock (circulatory) Exploratory Behavior Septum of Brain medicine.symptom Psychology 030217 neurology & neurosurgery Anterior hypothalamus |
| Zdroj: | Behavioural Brain Research. 314:16-20 |
| ISSN: | 0166-4328 |
| Popis: | Both the lateral septum (LS) and anterior hypothalamus (AHA) regulate behavioural defense. We tested whether those two interconnected structures act in serial in that regard. Infusions of the GABAA agonist muscimol into one side of the LS and the contralateral (but not ipsilateral) AHA suppressed rats' burying in the shock-probe test whereas none of our muscimol infusion approaches altered their open-arm avoidance in the elevated plus-maze. These results suggest that the LS-AHA circuit serves a specialized role in defensive responses towards discrete, localizable threat stimuli but not towards potential threats. |
| Databáze: | OpenAIRE |
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