Severe Tinnitus Induced by Off-Label Baclofen
| Autor: | Vincent Loche, Benjamin Rolland, Sylvie Deheul, Sophie Gautier, Régis Bordet, Olivier Cottencin, Catherine Hennaux, Marine Auffret |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Agonist Baclofen medicine.drug_class Off-label use Tinnitus chemistry.chemical_compound otorhinolaryngologic diseases medicine Humans Pharmacology (medical) Spasticity Dose-Response Relationship Drug Muscle Relaxants Central business.industry Alcohol dependence Off-Label Use Middle Aged medicine.disease Alcoholism nervous system chemistry GABA-B Receptor Agonists Anesthesia Etiology Female medicine.symptom business Adverse drug reaction |
| Zdroj: | Annals of Pharmacotherapy. 48:656-659 |
| ISSN: | 1542-6270 1060-0280 |
| DOI: | 10.1177/1060028014525594 |
| Popis: | Objective: The γ-aminobutyric acid type B (GABA-B) receptor agonist baclofen is approved for spasticity up to the dose of 80 mg/d. Recently, off-label use of high-dose baclofen (HDB), up to 400 mg/d, has been increasing for treating alcohol use disorders (AUDs), although the efficacy and safety profiles of HDB are relatively unknown. We report 2 cases of tinnitus in patients treated with HDB for AUD. Case Summaries: The first case concerns a 60-year-old man who reported tinnitus when he reached a 180 mg/d dose of baclofen after 3 months of treatment. Tinnitus persisted until the dose was reduced to 90 mg/d. The second case concerns a 45-year-old woman who presented with tinnitus when she reached a 210 mg/d dose of baclofen after 4 months of treatment. Tinnitus persisted until the dose was reduced to 60 mg/d. Discussion: Using the Naranjo scale, imputability to baclofen was considered probable in both cases. GABA-B receptors have been reported to be implicated in both the etiology and the treatment of tinnitus. There may be an individual susceptibility to develop tinnitus under baclofen therapy because of some GABA-B genetic polymorphisms that remain to be determined. Conclusion: HDB may be responsible for the occurrence of severe tinnitus, possibly in a dose-dependent manner. This appears to be coherent with the previously known involvement of GABA-B receptors in the pathophysiology of tinnitus. |
| Databáze: | OpenAIRE |
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