Fabrication and characterization of dissolving microneedles for transdermal drug delivery of allopurinol

Autor:	Jianmin Chen, Xinying Liu, Siwan Liu, Zemin He, Sijin Yu, Zhipeng Ruan, Nan Jin
Rok vydání:	2021
Předmět:	Pharmacology Drug Delivery Systems Microinjections Pharmaceutical Preparations Needles Allopurinol Organic Chemistry Drug Discovery Pharmaceutical Science Administration Cutaneous Skin
Zdroj:	Drug Development and Industrial Pharmacy. 47:1578-1586
ISSN:	1520-5762 0363-9045
Popis:	Allopurinol (AP) is the first line drug in treating hyperuricemia and gout in clinical by oral drug delivery, which is associated with severe adverse effects and the hepatic first-pass effect. Herein, we first proposed AP encapsulated dissolving microneedles (DMNs) for transdermal drug delivery to realize the sustained drug release and avoid the hepatic first-pass effect, which will help to reduce the adverse effects and improve the bioavailability of AP. DMNs were fabricated by a suspension solution casting method with precisely controlled dose. They had sufficient mechanical strength to penetrate through the skin and resulted in the formation of hundreds of micropores in skin. The results of
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97abaf9a570528e297f08fc6f56e679a https://doi.org/10.1080/03639045.2022.2027959 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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