Pediatric Midbrain Tumors: A Benign Subgroup of Brainstem Gliomas
| Autor: | James A. Brunberg, Robert C. Dauser, Karin M. Muraszko, Andrew T. Turrisi, Patricia L. Robertson, Richard A. Axtell |
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| Rok vydání: | 1995 |
| Předmět: |
Male
Pathology medicine.medical_specialty Adolescent Tegmentum Mesencephali Astrocytoma Ventriculoperitoneal Shunt Midbrain Central nervous system disease Glioma medicine Humans Neoplasm Midbrain tumors Child Brain Neoplasms business.industry General Medicine medicine.disease Magnetic Resonance Imaging Treatment Outcome Child Preschool Pediatrics Perinatology and Child Health Female Surgery sense organs Neurology (clinical) Brainstem Presentation (obstetrics) business Hydrocephalus |
| Zdroj: | Pediatric Neurosurgery. 22:65-73 |
| ISSN: | 1423-0305 1016-2291 |
| DOI: | 10.1159/000120879 |
| Popis: | The presentation, radiographic findings and course of 17 children with MRI-documented intrinsic midbrain lesions are reviewed. The anatomic centers of all the lesions were tectal, peritectal, or tegmental. Lesions centered at the pineal gland were excluded. Signs of increased intracranial pressure from hydrocephalus requiring shunt placement were present in 14 patients. Histopathological diagnosis was confirmed in three tumors; these were low grade astrocytomas and all received focal irradiation, as did one unbiopsied tumor. The remaining 13 patients with no histopathological diagnosis received no therapy other than shunt placement in 11. All but one of the lesions have remained clinically and radiographically stable, with a 4-year progression-free and total survival of 94 and 100%, respectively. We conclude that mass lesions originating in the upper midbrain are a subset of intrinsic brainstem tumors with a relatively benign course, usually presenting with hydrocephalus after infancy. They may remain stable for considerable periods and may require no further therapy after treatment of hydrocephalus. Surgical biopsy and/or resection can usually be reserved for progressive or atypical lesions which may also require further adjuvant therapy. |
| Databáze: | OpenAIRE |
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