Steroid-free three-drug maintenance regimen for pancreas transplant alone: Comparison of induction with rabbit antithymocyte globulin +/− rituximab
| Autor: | Tim E. Taber, Asif Sharfuddin, Arianna Cabrales, Richard S. Mangus, Jonathan A. Fridell, Jeanne Chen, Muhammad S. Yaqub, John A. Powelson |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Graft Rejection Male medicine.medical_specialty medicine.medical_treatment Urology 030230 surgery Tacrolimus Nephrotoxicity Diabetic nephropathy 03 medical and health sciences Postoperative Complications 0302 clinical medicine Risk Factors medicine Animals Humans Immunology and Allergy Pharmacology (medical) Antilymphocyte Serum Retrospective Studies Sirolimus Transplantation business.industry Graft Survival Immunosuppression Mycophenolic Acid Prognosis medicine.disease Regimen surgical procedures operative medicine.anatomical_structure Female 030211 gastroenterology & hepatology Rituximab Pancreas Transplantation Rabbits Pancreas business Immunosuppressive Agents Follow-Up Studies medicine.drug |
| Zdroj: | American Journal of Transplantation. 18:3000-3006 |
| ISSN: | 1600-6135 |
| Popis: | Graft survival following pancreas transplant alone (PTA) is inferior to other pancreas transplants. Steroid elimination is appealing, but a two-drug maintenance strategy may be inadequate. Additionally, recipients tend to have diabetic nephropathy and do not tolerate nephrotoxic medications. A three-drug maintenance strategy permits immunosuppression through different mechanisms as well as an opportunity to use lower doses of the individual medications. Induction consisted of five doses of rabbit antithymocyte globulin (1 mg/kg/dose). As of October 2007, a single dose of rituximab (150 mg/m2 ) was added. Maintenance consisted of tacrolimus, sirolimus and mycophenolate mofetil. From 2004 to 2017, 166 PTA were performed. Graft loss at 7 and 90 days were 4% and 5%, and 1-year patient and graft survival were 97% and 91%. Comparing induction without and with rituximab, there was no significant difference in 7- or 90-day graft loss, 1-year patient or graft survival, or in the rate of rejection or infection. Rabbit antithymocyte globulin induction and steroid withdrawal followed by a three-drug immunosuppression regimen is an excellent strategy for PTA recipients. |
| Databáze: | OpenAIRE |
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