Stages in LAV/HTLV-III Lymphadenitis
Autor: | Nielsen Cm, C S Petersen, Lars Mathiesen, Ebbe Dickmeiss, Jan Gerstoft, S. Kroon, Pallesen G, B. Ø. Lindhardt, Bo Hofmann |
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Rok vydání: | 1987 |
Předmět: |
Male
Pathology medicine.medical_specialty Biopsy Immunology Lymph node biopsy Immunoglobulins Lymphocyte Activation Lymphadenitis Follicular phase Humans Medicine Lymphocytes music Lymph node Acquired Immunodeficiency Syndrome music.instrument medicine.diagnostic_test business.industry Histology Homosexuality General Medicine Prognosis Follicular hyperplasia Persistent generalized lymphadenopathy medicine.anatomical_structure Lymph Nodes CD5 business |
Zdroj: | Scandinavian Journal of Immunology. 25:93-99 |
ISSN: | 1365-3083 0300-9475 |
DOI: | 10.1111/j.1365-3083.1987.tb01050.x |
Popis: | The aim of the present study was to investigate the relation between the histopathological findings in LAV/HTLV-III lymphadenitis and immunological, clinical, and serological variables. The study group included 38 consecutive homosexual men with persistent generalized lymphadenopathy (PGL) in whom lymph node biopsy was performed. The histopathological lymph node changes were grouped into three stages. Opportunistic infections at the time of biopsy and their development during follow-up were significantly associated with stage III histology (follicular depletion). Analysis of blood from 10 patients with stage III histology revealed significantly (P less than 0.01) decreased proliferative responses of lymphocytes to mitogens and reduced absolute number of CD5+ and CD4+ lymphocytes compared with 17 patients with stage I histology (follicular hyperplasia), whereas patients with stage II histology (follicular involution) had intermediate values. The absolute number of CD8+ lymphocytes was increased in all three stages, as was IgG, while increase in IgM and IgA was restricted to stage III. No difference was observed between the different histopathological stages with respect to the specificity of the anti-LAV/HTLV-III antibody as measured by immunoblotting. In conclusion, the defects of lymphocytes from the blood of LAV/HTLV-III infected persons reflect alterations in secondary lymphoid tissue. Further, there is a close correlation between these alterations and the clinical status of the patients. |
Databáze: | OpenAIRE |
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