Erythropoiesis in Malaria Infections and Factors Modifying the Erythropoietic Response
| Autor: | Kanjaksha Ghosh, Vrushali Pathak |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Ineffective erythropoiesis business.industry Anemia lcsh:RC633-647.5 Cell Biology Hematology Review Article lcsh:Diseases of the blood and blood-forming organs medicine.disease medicine.disease_cause Pathophysiology 03 medical and health sciences 030104 developmental biology medicine.anatomical_structure Immune system Immunology medicine Erythropoiesis Bone marrow Globin business Malaria |
| Zdroj: | Anemia, Vol 2016 (2016) Anemia |
| ISSN: | 2090-1275 2090-1267 |
| Popis: | Anemia is the primary clinical manifestation of malarial infections and is responsible for the substantial rate of morbidity. The pathophysiology discussed till now catalogued several causes for malarial anemia among which ineffective erythropoiesis being remarkable one occurs silently in the bone marrow. A systematic literature search was performed and summarized information on erythropoietic response upon malaria infection and the factors responsible for the same. This review summarizes the clinical and experimental studies on patients, mouse models, and in vitro cell cultures reporting erythropoietic changes upon malaria infection as well as factors accountable for the same. Inadequate erythropoietic response during malaria infection may be the collective effect of various mediators generated by host immune response as well as parasite metabolites. The interplay between various modulators causing the pathophysiology needs to be explored further. Globin gene expression profiling upon malaria infection should also be looked into as abnormal production of globin chains could be a possible contributor to ineffective erythropoiesis. |
| Databáze: | OpenAIRE |
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