Association of microRNA-125a with the clinical features, disease activity and inflammatory cytokines of juvenile-onset lupus patients
| Autor: | Eman Eissa, Naglaa Kholoussi, Rania Fawzy Mahmoud Abdelkawy, Hanan H. Ahmed, Botros Morcos |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Adult Male Adolescent Severity of Illness Index Proinflammatory cytokine Disease activity 03 medical and health sciences Interferon-gamma Young Adult 0302 clinical medicine Rheumatology microRNA medicine Humans Lupus Erythematosus Systemic Age of Onset 030203 arthritis & rheumatology Autoimmune disease Inflammation Lupus erythematosus Systemic lupus erythematosus business.industry Interleukin-17 medicine.disease Lupus Nephritis MicroRNAs 030104 developmental biology Juvenile onset Case-Control Studies Immunology Cytokines Egypt Female Interleukin 17 business |
| Zdroj: | Lupus. 30(7) |
| ISSN: | 1477-0962 |
| Popis: | Background Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with marked variation in its clinical presentation. Juvenile-onset SLE (jSLE) exhibits an aggressive clinical phenotype and severe complications. Dysregulated expression of microRNAs (miRs) in immune cells from patients with SLE has been found. We aim to evaluate the association of miR-125a with the clinical and laboratory characteristics, disease activity and inflammatory cytokines of jSLE patients. Methods 60 jSLE patients and 25 normal controls were involved in the study. The expression pattern of miR-125a was determined in plasma of all subjects using qRT-PCR. In addition, plasma levels of IL-17 and IFN-γ were examined using ELISA. The correlation of miR-125a expression with the clinical manifestations and disease activity of jSLE patients was analyzed. Also, its association with the inflammatory cytokines was investigated in jSLE patients. Results Our findings showed that miR-125a expression levels were significantly reduced in jSLE patients compared to normal controls ( p Conclusion Our findings postulate that miR-125a could act as a candidate therapeutic target for its possible regulation of inflammation in jSLE patients. |
| Databáze: | OpenAIRE |
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