Aptamers in Virology—A Consolidated Review of the Most Recent Advancements in Diagnosis and Therapy

Autor:	Ipsita Volety, Deepak Shukla, Tejabhiram Yadavalli
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	therapy Oligonucleotide SELEX diagnosis Aptamer viruses aptamers Pharmaceutical Science Review Biology Virology RS1-441 Pharmacy and materia medica Viral entry Aptamer Technology Systematic evolution of ligands by exponential enrichment Viral antigens
Zdroj:	Pharmaceutics, Vol 13, Iss 1646, p 1646 (2021) Pharmaceutics
ISSN:	1999-4923
Popis:	The use of short oligonucleotide or peptide molecules as target-specific aptamers has recently garnered substantial attention in the field of the detection and treatment of viral infections. Based on their high affinity and high specificity to desired targets, their use is on the rise to replace antibodies for the detection of viruses and viral antigens. Furthermore, aptamers inhibit intracellular viral transcription and translation, in addition to restricting viral entry into host cells. This has opened up a plethora of new targets for the research and development of novel vaccines against viruses. Here, we discuss the advances made in aptamer technology for viral diagnosis and therapy in the past decade.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97a2886853d41c16ef0e3b7bb986b1da https://www.mdpi.com/1999-4923/13/10/1646 Zobrazit plný text záznamu