Visualization Ability of Phase-Contrast Synchrotron-Based X-Ray Imaging Using an X-Ray Interferometer in Soft Tissue Tumors
| Autor: | Hiroko Maruyama, Akio Yoneyama, Thet-Thet Lwin, Tohoru Takeda |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Cancer Research Materials science Phase contrast microscopy Soft Tissue Neoplasms 030218 nuclear medicine & medical imaging law.invention 03 medical and health sciences Imaging Three-Dimensional 0302 clinical medicine Optics Testicular Neoplasms X-ray interferometer law High spatial resolution Animals Sensitivity (control systems) RC254-282 business.industry X-ray Neoplasms. Tumors. Oncology. Including cancer and carcinogens histopathological images Chromatin Synchrotron testicular tumors Rats Visualization Interferometry phase-contrast synchrotron-based X-ray imaging Oncology Original Article Tomography X-Ray Computed business Synchrotrons 030217 neurology & neurosurgery |
| Zdroj: | Technology in Cancer Research & Treatment, Vol 20 (2021) Technology in Cancer Research & Treatment |
| ISSN: | 1533-0338 |
| Popis: | Phase-contrast synchrotron-based X-ray imaging using an X-ray interferometer provides high sensitivity and high spatial resolution, and it has the ability to depict the fine morphological structures of biological soft tissues, including tumors. In this study, we quantitatively compared phase-contrast synchrotron-based X-ray computed tomography images and images of histopathological hematoxylin-eosin-stained sections of spontaneously occurring rat testicular tumors that contained different types of cells. The absolute densities measured on the phase-contrast synchrotron-based X-ray computed tomography images correlated well with the densities of the nuclear chromatin in the histological images, thereby demonstrating the ability of phase-contrast synchrotron-based X-ray imaging using an X-ray interferometer to reliably identify the characteristics of cancer cells within solid soft tissue tumors. In addition, 3-dimensional synchrotron-based phase-contrast X-ray computed tomography enables screening for different structures within tumors, such as solid, cystic, and fibrous tissues, and blood clots, from any direction and with a spatial resolution down to 26 μm. Thus, phase-contrast synchrotron-based X-ray imaging using an X-ray interferometer shows potential for being useful in preclinical cancer research by providing the ability to depict the characteristics of tumor cells and by offering 3-dimensional information capabilities. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|