TLR4 Deletion Improves Cognitive Brain Function and Structure in Aged Mice

Autor:	Xiaowei Fei, Ya-nan Dou, Weihao Lv, Boyun Ding, Jialiang Wei, Xiuquan Wu, Xin He, Zhou Fei, Fei Fei
Rok vydání:	2022
Předmět:	Inflammation Male Mice Inbred C57BL Mice Knockout Toll-Like Receptor 4 Mice Cognition Tight Junction Proteins General Neuroscience Animals Brain Gene Deletion
Zdroj:	Neuroscience. 492
ISSN:	1873-7544
Popis:	Toll-like receptor-4 (TLR4), a member of the TLR family, plays a key role in inflammation-related diseases of the nervous system. TLR4 knockout mice are widely used in various neurological disease studies, and there is a clear correlation between inflammation and behavior. Therefore, elucidating the effect of TLR4 on neurobehavioral function is essential, and the related mechanisms need to be explored. Male TLR4 knockout (TLR4
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::979aae29581004ab510f89566f867fca https://pubmed.ncbi.nlm.nih.gov/35405301 Zobrazit plný text záznamu Full Text from ScienceDirect