Cholinergic switch between two types of slow waves in cerebral cortex
| Autor: | Ulisse Ferrari, Trang-Anh Nghiem, Shayan Moghimyfiroozabad, Matteo di Volo, Thierry Bal, Bartosz Telenczuk, Tomasz Górski, Cristiano Capone, Alain Destexhe, Jennifer S. Goldman, Núria Tort-Colet |
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| Přispěvatelé: | PERIGNON, Alain, Biophysique et Neuroscience Théoriques, Laboratoire de physique de l'ENS - ENS Paris (LPENS), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-Département de Physique de l'ENS-PSL, École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-Département de Physique de l'ENS-PSL, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Institut des Neurosciences Paris-Saclay (NeuroPSI), Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Institut de la Vision, Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Istituto Nazionale di Fisica Nucleare, Sezione di Roma 3 (INFN, Sezione di Roma 3), Istituto Nazionale di Fisica Nucleare (INFN), Laboratoire de physique de l'ENS - ENS Paris (LPENS (UMR_8023)), École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)-Sorbonne Université (SU)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)-Sorbonne Université (SU)-École normale supérieure - Paris (ENS Paris) |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Sufentanil
[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology [SDV.NEU.PC] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior Sleep Slow-Wave memory Mice 0302 clinical medicine Parietal Lobe Neuromodulation Primary Visual Cortex Entorhinal Cortex Receptors Cholinergic Slow-wave sleep Cerebral Cortex Neurons Physics 0303 health sciences [SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior Motor Cortex [SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences Condensed Matter - Disordered Systems and Neural Networks Sleep in non-human animals Temporal Lobe 3. Good health medicine.anatomical_structure Cerebral cortex neuromodulation Excitatory postsynaptic potential Neurons and Cognition (q-bio.NC) Ketamine Memory consolidation Anesthetics Intravenous Agonist neural network models medicine.drug_class Cognitive Neuroscience FOS: Physical sciences Prefrontal Cortex Anesthesia General Cholinergic Agonists In Vitro Techniques anesthesia Inhibitory postsynaptic potential 03 medical and health sciences Cellular and Molecular Neuroscience Temporal statistics Memory formation medicine High activity Animals Humans Computer Simulation sleep Memory Consolidation 030304 developmental biology Acetylcholine receptor Anesthetics Dissociative [SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology Neural Inhibition Disordered Systems and Neural Networks (cond-mat.dis-nn) Brain Waves Rats FOS: Biological sciences Quantitative Biology - Neurons and Cognition Cats Macaca Cholinergic Neuroscience [SDV.NEU.SC] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences 030217 neurology & neurosurgery |
| Zdroj: | Cerebral Cortex Cerebral Cortex, 2020, 30 (6), pp.3451. ⟨10.1093/cercor/bhz320⟩ Cerebral Cortex, Oxford University Press (OUP), 2020, 30 (6), pp.3451. ⟨10.1093/cercor/bhz320⟩ |
| ISSN: | 1047-3211 1460-2199 |
| DOI: | 10.1101/430405 |
| Popis: | Sleep slow waves are known to participate in memory consolidation, yet slow waves occurring under anesthesia present no positive effects on memory. Here, we shed light onto this paradox, based on a combination of extracellular recordings in vivo, in vitro, and computational models. We find two types of slow waves, based on analyzing the temporal patterns of successive slow-wave events. The first type is consistently observed in natural slow-wave sleep, while the second is shown to be ubiquitous under anesthesia. Network models of spiking neurons predict that the two slow wave types emerge due to a different gain on inhibitory vs excitatory cells and that different levels of spike-frequency adaptation in excitatory cells can account for dynamical distinctions between the two types. This prediction was tested in vitro by varying adaptation strength using an agonist of acetylcholine receptors, which demonstrated a neuromodulatory switch between the two types of slow waves. Finally, we show that the first type of slow-wave dynamics is more sensitive to external stimuli, which can explain how slow waves in sleep and anesthesia differentially affect memory consolidation, as well as provide a link between slow-wave dynamics and memory diseases. 37 pages, 5 main figures, 4 supplementary figures |
| Databáze: | OpenAIRE |
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