Increased systemic Th17 cytokines are associated with diastolic dysfunction in children and adolescents with diabetic ketoacidosis

Autor: Glenn D. Harris, Cynthia Keel, Irma Fiordalisi, Noel R. Rose, Catherine Brailer, Monica V. Talor, William H. Hoffman, Gregory G. Passmore, David W. Hannon, Daniela Cihakova, Dynita Haislip, Pam Fox
Rok vydání: 2013
Předmět:
Male
endocrine system diseases
medicine.medical_treatment
Cardiovascular
Gastroenterology
Pediatrics
Diagnostic Radiology
Ventricular Dysfunction
Left
Endocrinology
Diastole
Diabetic cardiomyopathy
Pediatric Cardiology
Child
Multidisciplinary
Cytokine
Echocardiography
Hypertension
Cytokines
Medicine
Female
Inflammation Mediators
Radiology
Research Article
medicine.medical_specialty
Diabetic ketoacidosis
Adolescent
Science
CCL7
Proinflammatory cytokine
Diabetic Ketoacidosis
Autoimmune Diseases
Internal medicine
Diabetes mellitus
medicine
Humans
Inflammation
Diabetic Endocrinology
business.industry
Immunity
nutritional and metabolic diseases
Diabetes Mellitus Type 1
medicine.disease
Systemic inflammatory response syndrome
Diabetes Mellitus
Type 1
Immune System
Immunology
Th17 Cells
Clinical Immunology
business
Zdroj: PLoS ONE
PLoS ONE, Vol 8, Iss 8, p e71905 (2013)
ISSN: 1932-6203
Popis: Diastolic dysfunction suggestive of diabetic cardiomyopathy is established in children with T1DM, but its pathogenesis is not well understood. We studied the relationships of systemic inflammatory cytokines/chemokines and cardiac function in 17 children with T1DM during and after correction of diabetic ketoacidosis (DKA). Twenty seven of the 39 measured cytokines/chemokines were elevated at 6–12 hours into treatment of DKA compared to values after DKA resolution. Eight patients displayed at least one parameter of diastolic abnormality (DA) during acute DKA. Significant associations were present between nine of the cytokine/chemokine levels and the DA over time. Interestingly, four of these nine interactive cytokines (GM-CSF, G-CSF, IL-12p40, IL-17) are associated with a Th17 mediated cell response. Both the DA and CCL7 and IL-12p40, had independent associations with African American patients. Thus, we report occurrence of a systemic inflammatory response and the presence of cardiac diastolic dysfunction in a subset of young T1DM patients during acute DKA.
Databáze: OpenAIRE
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