The impact of thyroid hormones on patients with hepatocellular carcinoma
| Autor: | Wolfgang Sieghart, F. Hucke, Simona Bota, Matthias Pinter, Lukas Haupt, Michael Trauner, Theresa Bucsics, Markus Peck-Radosavljevic |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Oncology
Male RNA viruses Etiology Peptide Hormones Thyroid Gland lcsh:Medicine Hepacivirus Thyroid Function Tests Biochemistry 0302 clinical medicine Endocrinology Mathematical and Statistical Techniques Medicine and Health Sciences lcsh:Science 10. No inequality Pathology and laboratory medicine Aged 80 and over Thyroid Univariate analysis Multidisciplinary medicine.diagnostic_test Hepatitis C virus Liver Diseases Liver Neoplasms Middle Aged Medical microbiology Prognosis 3. Good health medicine.anatomical_structure 030220 oncology & carcinogenesis Hepatocellular carcinoma Physical Sciences Viruses 030211 gastroenterology & hepatology Female Anatomy Pathogens hormones hormone substitutes and hormone antagonists Statistics (Mathematics) Research Article Adult medicine.medical_specialty Thyroid Hormones Carcinoma Hepatocellular Endocrine Disorders Endocrine System Gastroenterology and Hepatology Research and Analysis Methods Thyroid function tests Carcinomas Microbiology 03 medical and health sciences Hypothyroidism Internal medicine Gastrointestinal Tumors medicine Carcinoma Biomarkers Tumor Humans Statistical Methods Thyroid-Stimulating Hormone Aged Retrospective Studies Flaviviruses business.industry lcsh:R Organisms Viral pathogens Biology and Life Sciences Cancers and Neoplasms Retrospective cohort study Hepatocellular Carcinoma Hepatology medicine.disease Hormones Hepatitis viruses Microbial pathogens Multivariate Analysis lcsh:Q business Mathematics Hormone |
| Zdroj: | PLoS ONE PLoS ONE, Vol 12, Iss 8, p e0181878 (2017) |
| ISSN: | 1932-6203 |
| Popis: | Background & aims Hypothyroidism has recently been proposed as predisposing factor for HCC development. However, the role of thyroid hormones (TH) in established HCC is largely unclear. We investigated the impact of TH on clinical characteristics and prognosis of HCC patients. Methods Of 838 patients diagnosed with nonsurgical HCC at the Division of Gastroenterology and Hepatology/Medical University of Vienna between 1992 and 2012, 667 patients fulfilled the inclusion criteria. The associations of thyroid function tests with patient, liver, and tumor characteristics as well as their impact on overall survival (OS) were investigated. Results Thyroid hormone substitution was more often observed in patients with low thyroid-stimulating hormone (TSH) concentration and in patients with elevated free tetraiodthyronine (fT4). Patients with high TSH (>3.77uU/ml) concentrations had larger tumors, while the opposite was true for patients with low TSH (1.66ng/dl) were more likely to have elevated CRP. While TSH was only associated with OS in univariate analysis (≤1.7 vs. >1.7uU/ml, median OS (95%CI), 12.3 (8.9–15.7 months) vs. 7.3 months (5.4–9.2 months); p = 0.003), fT4 (≤1.66 vs. >1.66ng/dl, median OS (95%CI), 10.6 (7.5–13.6 months) vs. 3.3 months (2.2–4.3 months); p = 0.007) remained an independent prognostic factor for OS (HR (95%CI) for fT4>1.66ng/dl, 2.1 (1.3–3.3); p = 0.002) in multivariate analysis. Conclusions TSH and fT4 were associated with prognostic factors of HCC (i.e., tumor size, CRP level). Elevated fT4 concentrations were independently associated with poor prognosis in HCC. Further studies are needed to characterize the role of TH in HCC in detail. |
| Databáze: | OpenAIRE |
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