Alveolar soft part sarcoma: the new primary intracranial malignancy
Autor: | Aditaya Kumar, W. Taylor, P. Bhattathiri, B. Alrohmain |
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Rok vydání: | 2017 |
Předmět: |
medicine.medical_specialty
Fossa biology business.industry medicine.medical_treatment General Medicine Disease Left posterior Malignancy medicine.disease biology.organism_classification 030218 nuclear medicine & medical imaging Surgery Radiation therapy 03 medical and health sciences 0302 clinical medicine Radiological weapon Alveolar soft part sarcoma medicine Medical imaging Neurology (clinical) business 030217 neurology & neurosurgery |
Zdroj: | Neurosurgical Review. 42:23-29 |
ISSN: | 1437-2320 0344-5607 |
Popis: | The purpose of this paper is to serve as a reference to aid in the management of this poorly understood intracranial malignancy. The authors report their experience treating the eighth ostensible case of a primary intracranial alveolar soft part sarcoma (ASPS). A 21-year-old man presented to hospital after collapsing. He gave a 1-year history of headache, a 2-month history of reduced visual acuity and on examination had left facial paraesthesia with left-sided incoordination. MRI of the brain revealed a large left posterior fossa mass. The patient underwent resection of the tumour with good recovery in function. Immunohistochemical analysis of the tumour specimen confirmed an ASPS, and multimodal imaging in search of an extra-cranial disease primary was negative. A review of the literature yielded only seven other cases of primary intracranial ASPS. A variety of diagnostic imaging modalities were employed in search of a disease primary, as were various combinations of surgical resection, chemotherapy and radiotherapy as treatment. Half of the cases documented delayed disease recurrence. The authors discuss the following: the unique radiological and immunohistological characteristics of this disease including the potential for its misdiagnosis; the investigations required to diagnose a primary intracranial ASPS; the efficacy of current medical and surgical treatment options and the factors that will aid in prognostication. This is the first review of this new primary intracranial malignancy. From our analysis, we offer a joint radiological and immunohistochemical algorithm for the diagnosis of primary intracranial ASPS and specific operative considerations prior to resection. |
Databáze: | OpenAIRE |
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