Urinary albumin excretion as a predictor of the development of hypertension in the general population
| Autor: | Dick de Zeeuw, Stephan J. L. Bakker, Paul E. de Jong, Auke H. Brantsma, Ron T. Gansevoort |
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| Přispěvatelé: | Cardiovascular Centre (CVC), Groningen Institute for Organ Transplantation (GIOT), Lifestyle Medicine (LM), Groningen Kidney Center (GKC) |
| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: |
Nephrology
Adult Male medicine.medical_specialty RENAL INJURY BLOOD-PRESSURE PROGRESSION Population Risk Assessment DISEASE KIDNEY Predictive Value of Tests Internal medicine medicine Albuminuria Humans Prospective Studies Risk factor Prospective cohort study education RISK education.field_of_study Proteinuria business.industry Incidence MICROALBUMINURIA General Medicine Odds ratio Middle Aged medicine.disease LOW-GRADE ALBUMINURIA C-REACTIVE PROTEIN SALT-SENSITIVE HYPERTENSION Endocrinology Blood pressure Logistic Models Case-Control Studies Hypertension Microalbuminuria Female medicine.symptom business Glomerular Filtration Rate |
| Zdroj: | Journal of the American Society of Nephrology, 17(2), 331-335. AMER SOC NEPHROLOGY |
| ISSN: | 1046-6673 |
| Popis: | The hypothesis that high urinary albumin excretion (UAE; indicating mild renal damage) may precede development of hypertension was tested, and the relation among UAE, GFR, and development of hypertension was investigated. Data of 4635 patients of a prospective cohort study who participated in an extensive screening in 1997 to 1998 and 2001 to 2003 at our outpatient unit and were normotensive at baseline were used. Hypertension was defined according to the Seventh Report of the joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure criteria, UAE was measured in two consecutive 24-h urine samples, and GFR was calculated with the modified Modification of Diet in Renal Disease formula. Mean follow-up was 4.3 yr. Baseline UAE was significantly associated with the risk for developing hypertension (odds ratio 2.29; 95% confidence interval 1.77 to 2.95 per 10-fold increase of UAE). This association was independent of potential confounders. An interaction between UAE and GFR was found (P = 0.030), indicating that with elevated UAE and lowered GFR, but still within the normal range, the risk for developing hypertension was highest. In conclusion, these findings support the hypothesis that mild renal damage may precede the development of hypertension. |
| Databáze: | OpenAIRE |
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