Effect of different immunosuppressive therapies on the lipid pattern in kidney-transplanted rats
| Autor: | Natalia Raquel Lausada, Camihort Gisela, Luna Georgina, Raimondi Clemente, T. De Gómez Dumm Nelva |
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| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_specialty Linoleic acid Hyperlipidemias Kidney Methylprednisolone chemistry.chemical_compound Membrane Lipids Oral administration Internal medicine Testis medicine Animals Urea Rats Wistar Triglycerides Antibacterial agent Diminution Sirolimus Transplantation Triglyceride Cholesterol business.industry Erythrocyte Membrane Lipid Metabolism Kidney Transplantation Lipids Rats Endocrinology chemistry Cydosporine Creatinine Ciencias Médicas Cyclosporine Microsomes Liver Prednisone Polyunsaturated fatty acids Arachidonic acid business Immunosuppressive Agents |
| Zdroj: | SEDICI (UNLP) Universidad Nacional de La Plata instacron:UNLP |
| ISSN: | 0934-0874 |
| Popis: | We analyzed the effect of oral administration of cyclosporine- methylprednisone (CsA-MP) and sirolimus (SRL) on the lipid pattern of kidney-transplanted rats after a 7-day survival. A significant increase in plasma cholesterol in CsA-MP group (control: 26 ± 3 mg/dl vs. 59 ± 8 mg/dl, P < 0.05) and in triglyceride levels in SRL group (control: 53 ± 4 mg/dl vs. 114 ± 3 mg/dl, P < 0.05), was shown. Kidney microsomal membranes from both treated groups showed that cholesterol and triglyceride values and the relative percentage of arachidonic acid in the total amount of n-6 fatty acids decreased. A diminution of linoleic acid occurred in testis (control: 9.4 ± 0.1 mg/dl vs. CsA-MP: 6.0 ± 0.3 mg/dl and vs. SRL: 6.8 ± 0.2 mg/dl, P < 0.05), liver (control: 17.7 ± 0.6 mg/dl vs. CsA-MP: 15.1 ± 0.6 mg/dl and SRL: 13.5 ± 0.8 mg/dl, P < 0.05) and erythrocyte membranes (control:11.7 ± 0.1% vs. CsA-MP: 10.6 ± 0.2% and SRL: 10.0 ± 0.4%, P < 0.01). The immunosuppressive therapies improved the rejection rate of the graft, fact that was remarkable in the SRL-treated group. However, lipid abnormalities still remain in spite of immunosuppressive therapies. (150). Facultad de Ciencias Médicas |
| Databáze: | OpenAIRE |
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