Loss of Local Tumor Control After Index Surgery for Spinal Metastases

Autor: Federico Ricciardi, Bernhard Meyer, Norio Kawahara, Maarten H. Coppes, Yasuaki Tokuhashi, F. C. Oner, Michael Wang, Jorrit Jan Verlaan, Chun Kee Chung, Juan Antonio Martin-Benlloch, Cody Bünger, Yee Ling Leung, Katsuro Tomita, Laurent Balabaud, Nasir A. Quraishi, Chong Suh Lee, Christian Mazel, David Choi, Eric M. Massicotte, Jacob M. Buchowski, Mark P. Arts, Christian Ulbricht, Bart Depreitere, Michael G. Fehlings, Hugh Alan Crockard, Wilco C. Peul
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Male
Repeat Surgery
Kaplan-Meier Estimate
Metastases
INDEPENDENT PREDICTORS
0302 clinical medicine
Quality of life
Recurrence
QUALITY-OF-LIFE
Medicine
Prospective Studies
Prospective cohort study
Repeat surgery
Tumor
Incidence (epidemiology)
Middle Aged
Primary tumor
Tumor recurrence
Treatment Outcome
Spinal Neoplasms/mortality
030220 oncology & carcinogenesis
SURGICAL-TREATMENT
SURVIVAL
Female
Spinal metastases
Life Sciences & Biomedicine
Reoperation
medicine.medical_specialty
LUMBAR SPINE
CLINICAL ARTICLE
Clinical Neurology
03 medical and health sciences
MANAGEMENT
Humans
Karnofsky Performance Status
Neoplasm Recurrence
Local/mortality
Reoperation/mortality
Science & Technology
Spinal Neoplasms
business.industry
Tumor control
medicine.disease
Spine
Surgery
EN-BLOC SPONDYLECTOMY
Neurology (clinical)
Neurosciences & Neurology
Neoplasm Recurrence
Local
business
030217 neurology & neurosurgery
CORD COMPRESSION
Zdroj: World neurosurgery, 117, E8-E16. ELSEVIER SCIENCE INC
WORLD NEUROSURGERY
r-FISABIO: Repositorio Institucional de Producción Científica
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
World Neurosurgery, 117, E8-E16
r-FISABIO. Repositorio Institucional de Producción Científica
instname
Depreitere, B, Ricciardi, F, Arts, M, Balabaud, L, Buchowski, J M, Bunger, C, Chung, C K, Coppes, M H, Fehlings, M G, Kawahara, N, Lee, C-S, Leung, Y, Martin-Benlloch, J A, Massicotte, E M, Mazel, C, Meyer, B, Oner, F C, Peul, W, Quraishi, N, Tokuhashi, Y, Tomita, K, Ulbricht, C, Verlaan, J J, Wang, M, Crockard, H A & Choi, D 2018, ' Loss of Local Tumor Control After Index Surgery for Spinal Metastases : A Prospective Cohort Study ', World Neurosurgery, vol. 117, pp. e8-e16 . https://doi.org/10.1016/j.wneu.2018.04.170
ISSN: 1878-8769
1878-8750
DOI: 10.1016/j.wneu.2018.04.170
Popis: BACKGROUND: As survival after treatment for symptomatic spinal metastases increases, the incidence of local tumor recurrence also may increase. However, data regarding incidence and timing of recurrence or duration of survival after second surgeries are not readily available and may help to inform clinicians when to perform second surgeries. OBJECTIVE: To identify features associated with loss of local control (LLC) at a previously treated or new spinal level. METHODS: Clinical and surgical data were collected from a prospective cohort of 1421 patients who had surgery for symptomatic spinal metastases. Patients undergoing repeat spinal surgery for symptomatic LLC at the same or a different level were identified and analyzed. RESULTS: In total, 3.0% patients underwent repeat surgery for symptomatic LLC after a median interval of 184 days from the first surgery; median survival was 6.1 months after second surgery. Factors associated with second surgery for LLC were the primary tumor type, number of spinal levels, Tomita staging, Tokuhashi and Karnofsky scores, anterior surgical approach, more aggressive surgical resection, and postoperative radiotherapy. In total, 1.5% patients were admitted for surgery for a different spinal level than the index operation after median 338 days from the first operation. CONCLUSIONS: The likelihood for repeat surgery due to LLC cannot be accurately predicted at the time of initial presentation. Factors associated with second surgery for LLC relate to less aggressive tumor biology and better survival. Most patients had a reasonable duration of survival after second surgery. ispartof: WORLD NEUROSURGERY vol:117 pages:E8-E16 ispartof: location:United States status: published
Databáze: OpenAIRE
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