Influence of HLA on clinical and analytical features of pediatric celiac disease
| Autor: | Eva Martínez-Ojinaga, Concepción Núñez, Manuel Molina, Isabel Polanco, Marta Fernández-Prieto, Elena Urcelay |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Genotype Logistic regression Gastroenterology Severity of Illness Index Serology GTP-Binding Proteins Internal medicine HLA-DQ Antigens HLA-DQ Diagnosis medicine Humans Genetic Predisposition to Disease Protein Glutamine gamma Glutamyltransferase 2 Family history lcsh:RC799-869 Autoantibodies Retrospective Studies Transglutaminases business.industry Homozygote Retrospective cohort study General Medicine Hepatology Endomysium Exact test Celiac Disease medicine.anatomical_structure Logistic Models Child Preschool Multivariate Analysis Female lcsh:Diseases of the digestive system. Gastroenterology Clinical symptoms Atrophy business Research Article |
| Zdroj: | BMC Gastroenterology, Vol 19, Iss 1, Pp 1-6 (2019) BMC Gastroenterology |
| DOI: | 10.1186/s12876-019-1014-0 |
| Popis: | Background Celiac disease (CD) is triggered by gluten and related prolamines in genetically susceptible individuals. We aimed to investigate the influence of HLA-DQ genotypes in clinical, serological and histological features related to CD. Methods A retrospective observational study was performed including 463 Spanish patients with biopsy-proven CD. Clinical, serological, histological and HLA-DQ genetic data were collected from each participant. The presence of a family history of CD was also considered. Bivariate (chi-square tests or the Fisher’s exact test) and multivariate (logistic regression after adjusting for age and sex) analyses were performed to assess the association between clinical and laboratory parameters with HLA-DQ. Results A predominance of females (62%), classical clinical presentation (86%) and positive anti-transglutaminase 2/endomysium antibodies (99%) was observed in our sample, with a mean age at onset of 2.6 ± 0.1 years. Five percent of our patients were first-degree relatives of subjects with CD, with HLA-DQ genetics showing increased homozygosity of HLA-DQ2.5 (p = 0.03) and HLA-DQ8 (p = 0.09). In the non-CD family history group, an association between delayed disease onset and HLA-DQ8 carriage was observed (p |
| Databáze: | OpenAIRE |
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