Breast Milk Exposure is Associated With Cortical Maturation in Preterm Infants

Autor: Gemma Sullivan, Kadi Vaher, Manuel Blesa, Paola Galdi, David Q. Stoye, Alan J. Quigley, Michael J. Thrippleton, John Norrie, Mark E. Bastin, James P. Boardman
Rok vydání: 2022
Předmět:
Zdroj: Sullivan, G, Vaher, K, Blesa, M, Galdi, P, Stoye, D Q, Quigley, A J, Thrippleton, M J, Norrie, J, Bastin, M E & Boardman, J P 2022, ' Breast milk exposure is associated with cortical maturation in preterm infants ', Annals of Neurology, vol. 93, no. 3, pp. 591-603 . https://doi.org/10.1002/ana.26559
ISSN: 1531-8249
0364-5134
DOI: 10.1002/ana.26559
Popis: OBJECTIVE: Breast milk exposure is associated with improved neurocognitive outcomes following preterm birth but the neural substrates linking breast milk with outcome are uncertain. We tested the hypothesis that high versus low breast milk exposure in preterm infants results in cortical morphology that more closely resembles that of term-born infants.METHODS: We studied 135 preterm (RESULTS: In preterm infants, high breast milk exposure was associated with reduced cortical gray matter volume (d = 0.47, 95% confidence interval [CI] = 0.14 to 0.94, p = 0.014), thickness (d = 0.42, 95% CI = 0.08 to 0.84, p = 0.039), and RD (d = 0.38, 95% CI = 0.002 to 0.77, p = 0.039), and increased FA (d = -0.38, 95% CI = -0.74 to -0.01, p = 0.037) after adjustment for age at MRI, which was similar to the cortical phenotype observed in term-born controls. Breast milk exposure quartile was associated with cortical volume (ß = -0.192, 95% CI = -0.342 to -0.042, p = 0.017), FA (ß = 0.223, 95% CI = 0.075 to 0.372, p = 0.007), and RD (ß = -0.225, 95% CI = -0.373 to -0.076, p = 0.007) following adjustment for age at birth, age at MRI, and weighted by propensity scores, suggesting a dose effect.INTERPRETATION: High breast milk exposure following preterm birth is associated with a cortical imaging phenotype that more closely resembles the brain morphology of term-born infants and effects appear to be dose-dependent. ANN NEUROL 2022.
Databáze: OpenAIRE
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