Identification of Periopathogens in Atheromatous Plaques Obtained from Carotid and Coronary Arteries
| Autor: | Danijela Staletovic, Verica Pavlic, Marwa Madi, Ivana Stosovic Kalezic, Dejan Peric, Zlata Brkic, Subraya G Bhat |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine Gingival and periodontal pocket medicine.medical_treatment Carotid endarterectomy Aggregatibacter actinomycetemcomitans Polymerase Chain Reaction Prevotella intermedia Gastroenterology 0302 clinical medicine Risk Factors RNA Ribosomal 16S Tannerella forsythia biology Treponema denticola General Medicine Middle Aged Coronary Vessels Plaque Atherosclerotic Carotid Arteries medicine.anatomical_structure Medicine Female Porphyromonas gingivalis Research Article Artery Adult medicine.medical_specialty Article Subject General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Internal medicine medicine Humans Periodontal Probing Periodontal Diseases Aged Inflammation General Immunology and Microbiology business.industry 030206 dentistry Vascular surgery Atherosclerosis biology.organism_classification Coronary arteries 030104 developmental biology business |
| Zdroj: | BioMed Research International BioMed Research International, Vol 2021 (2021) |
| ISSN: | 2314-6141 2314-6133 |
| Popis: | Increasing attention has been paid to the possible link between periodontal disease and atherosclerosis over the past decade. The aim of this study is to investigate the presence of five periopathogens: Porphyromonas gingivalis (P.g.), Aggregatibacter actinomycetemcomitans (A.a.), Tannerella forsythia (T.f.), Treponema denticola (T.d.), and Prevotella intermedia (P.i.) in atheromatous plaques obtained from the carotid and coronary arteries in patients who underwent coronary artery bypass graft surgery and carotid endarterectomy. Group I (carotid arteries) consisted of 30 patients (mean age: 54.5 ± 14.8 ), and group II (coronary arteries) consisted of 28 patients (mean age: 63 ± 12.1 ). Clinical periodontal examinations consisted of plaque index, gingival index, sulcus bleeding index, and periodontal probing depth and were performed on the day of vascular surgery. The presence of periopathogens in periodontal pockets and atherosclerotic vessels was detected using polymerase chain reaction. In both subgingival plaque and atherosclerotic plaque of carotid arteries, P.g., A.a., T.f., T.d., and P.i. were detected in 26.7%, 6.7%, 66.7%, 10.0%, and 20.0%, respectively, while for coronary arteries, P.g. was detected in 39.3%, A.a. in 25%, T.f. in 46.4%, T.d. in 7.1%, and P.i. in 35.7%. The presence of five periopathogens in carotid and coronary atherosclerotic vessels showed correlation in regard to the degree of periodontal inflammation. The present study suggests the relationship between periodontal pathogenic bacteria and atherogenesis. Further studies are necessary in relation to the prevention or treatment of periodontal disease that would result in reduced mortality and morbidity associated with atherosclerosis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|