Fulminant pseudomembranous colitis caused by Clostridium difficile PCR ribotype 027 in a healthy young woman in Japan
| Autor: | Masaki Watanabe, Haru Kato, Shujiro Yazumi, Satoshi Nishimura, Tadayuki Kou, Atsuko Hata, Tadashi Fukuda, Mitsutoshi Senoh, Shoichi Uno |
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| Rok vydání: | 2014 |
| Předmět: |
Microbiology (medical)
Adult Fulminant Virulence Polymerase Chain Reaction Ribotyping Microbiology law.invention Bacterial Proteins Japan Moxifloxacin law medicine Humans Pharmacology (medical) Colitis Polymerase chain reaction Enterocolitis Pseudomembranous business.industry Clostridioides difficile Pseudomembranous colitis Sequence Analysis DNA Clostridium difficile medicine.disease Gatifloxacin Infectious Diseases Female business medicine.drug |
| Zdroj: | Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy. 20(11) |
| ISSN: | 1437-7780 |
| Popis: | In the past two decades, Clostridium difficile polymerase chain reaction ribotype 027 strain has rapidly emerged as the leading cause of antibiotic-associated colitis in North America and Europe; however, it has been reported only occasionally in Japan. We report a case of fulminant pseudomembranous colitis caused by this strain in a healthy young woman in Japan without any previous medical history. The strain isolated from our patient was susceptible to both gatifloxacin and moxifloxacin, thus representing a historic strain. The acquisition of fluoroquinolone resistance was reported as the important key genetic event linked to the virulence of this strain. It is noteworthy that the fluoroquinolone-susceptible 027 strain caused fulminant colitis in a healthy young woman in a non-endemic area. Our experience suggests that C. difficile PCR ribotype 027 has the potential virulence factors that are not associated with a fluoroquinolone resistance-conferring mutation. |
| Databáze: | OpenAIRE |
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