Investigation of Cytomegalovirus in Intestinal Tissue in a Country With High CMV Seroprevalence
| Autor: | Hale Akpinar, Vildan Avkan-Oguz, Ozgul Sagol, Hande Hazır-Konya, Arzu Sayiner |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Adolescent Congenital cytomegalovirus infection Cytomegalovirus Gastroenterology Inflammatory bowel disease law.invention law Seroepidemiologic Studies Internal medicine medicine Seroprevalence Humans Ileitis Prospective Studies Polymerase chain reaction business.industry Gold standard (test) medicine.disease Colitis Inflammatory Bowel Diseases Staining Cross-Sectional Studies Cytomegalovirus Infections DNA Viral Immunohistochemistry Original Article business |
| Zdroj: | Turk J Gastroenterol |
| Popis: | BACKGROUND: In Turkey, cytomegalovirus (CMV) seropositivity has been reported to be high, between 85 and 100%. CMV has been responsible for disease exacerbation in inflammatory bowel disease (IBD). We aimed to evaluate the presence of CMV in intestinal tissue by immunohistochemical staining in IBD and non-IBD patient groups, in a country with high CMV seroprevalence. METHODS: In this prospective cross-sectional study, the presence of intestinal CMV was investigated with tissue immunohistochemistry (IHC) staining, which is accepted as the gold standard method, and with polymerase chain reaction (PCR) in tissue and blood. Patients (≥18 years old, n = 189) who had a colonoscopic biopsy between January and May 2017 were included in the study at our hospital. Clinical, laboratory, endoscopic, and histopathological data of patients were assessed by dividing them into IBD (n = 34) and non-IBD (n = 155) groups. RESULTS: In this study, 567 colonic biopsy samples from 189 patients were evaluated. Tissue IHC staining was positive for 3 (1.58%) non-IBD patients. One of them was diagnosed as CMV ileitis. CMV DNA was also detected in 14 plasma (7.40% |
| Databáze: | OpenAIRE |
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