Evaluation of Reproductive Toxicology of Aqueous Extract of Yerba Mate (Ilex paraguariensis A. St.-Hil.), a Traditional South American Beverage
| Autor: | Bruno Henrique Lopes Botelho Lourenço, Michelle de Paula Reis, Emerson Luiz Botelho Lourenço, Salviano Tramontin Belettini, Arquimedes Gasparotto Junior, Guilherme Donadel, Euclides Lara Cardozo Junior, Marcia Alessandra Arantes Marques, Francislaine Aparecida dos Reis Lívero, Ezilda Jacomassi, Washington Rogério de Sousa |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Reproductive toxicology Organogenesis Medicine (miscellaneous) Biology Aquifoliaceae Fetal Development 03 medical and health sciences Fetus 0302 clinical medicine food Ilex paraguariensis Pregnancy Yerba-mate Animals Rats Wistar Aqueous extract 030109 nutrition & dietetics Nutrition and Dietetics Traditional medicine Reproduction Contraindications Drug South America food.food Plant Leaves 030220 oncology & carcinogenesis South american Female Teas Herbal |
| Zdroj: | Journal of Medicinal Food. 22:97-101 |
| ISSN: | 1557-7600 1096-620X |
| Popis: | Yerba mate (Ilex paraguariensis A. St.-Hil.; Aquifoliaceae) is a popular tonic and stimulant beverage that is widely consumed in different South American countries. Estimates indicate the consumption of1 L per day in southern Brazil and Uruguay. Despite its relatively high consumption, data on reproductive toxicity during critical periods of gestation remain unclear. Thus, we evaluated the effects of an aqueous extract of I. paraguariensis leaves ("chimarrão" [IPC]) at two critical periods of gestation in Wistar rats: preimplantation embryonic stage and fetal organogenesis. Pregnant Wistar rats were orally treated with IPC (3, 30, and 300 mg/kg) from days 1 to 7 or 8 to 21 of pregnancy. The respective control groups received vehicle. During treatment, clinical signs of maternal toxicity, maternal body weight, and food and water intake were monitored. The rats were killed on days 8 and 20 of pregnancy, and the following parameters were evaluated: weight of the maternal uterus, weight of the liver, weight of the kidneys, weight of the spleen, total embryo implantation, preimplantation loss, the mean of live fetuses, the percentage of dead fetuses, fetus weight, and fetal malformation. The aqueous extract of the leaves of I. paraguariensis L. did not present any deleterious effects on preimplantation embryos or the organogenesis of offspring from female Wistar rats. These safety data provide evidence that IPC may be safe for consumption during gestation. |
| Databáze: | OpenAIRE |
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