The action of chlormadinone acetate on the estradiol uptake by rat organ cultures
| Autor: | Martha de Oliveira Guerra, Greta Declercq de Pérez Bedés, Jorge M. Rosner |
|---|---|
| Rok vydání: | 1972 |
| Předmět: |
medicine.medical_specialty
Chlormadinone Acetate Uterus Hypothalamus Biology Pharmacology Chlormadinone acetate chemistry.chemical_compound Internal medicine Culture Techniques medicine Endocrine system Animals Binding site neoplasms Estradiol Obstetrics and Gynecology Antiestrogen Rats medicine.anatomical_structure Endocrinology chemistry Hormone receptor Female hormones hormone substitutes and hormone antagonists Hormone |
| Zdroj: | American journal of obstetrics and gynecology. 112(3) |
| ISSN: | 0002-9378 |
| Popis: | The action of chlormadinone acetate on the estradiol uptake by rat organ cultures was investigated. Rat hypothalami and uteri tissue were incubated in TC 199 medium for 49 or 72 hours with tritiated estradiol-17beta and unlabeled estradiol or chlormadinone acetate. Chlormadinone acetate added simultaneously to tritiated estradiol inhibited the estradiol uptake (p less than .01) and when added 24 hours previously, the uptake increased (p less than .01) in both uterus and hypothalamus. Unlabeled estradiol also diminished (p less than .01) the estradiol uptake when added simultaneously and increased its uptake when added prior to tritiated estradiol-17beta. These results may indicate an estrogeniclike effect of chlormadinone acetate, perhaps by increasing the binding sites. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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