Resveratrol inhibits aggregation of platelets from high-risk cardiac patients with aspirin resistance
| Autor: | Zoltan Ungvari, Gyorgyi Stef, Anna Csiszar, Kenneth M. Lerea, Gabor Veress |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
Male Heart Diseases Platelet Aggregation Drug Resistance Pharmacology Resveratrol chemistry.chemical_compound Stilbenes medicine Humans Platelet ASPIRIN RESISTANCE Caloric restriction mimetic Aged Aspirin food and beverages Middle Aged medicine.disease Thrombosis Adenosine diphosphate surgical procedures operative Epinephrine Biochemistry chemistry Female Cardiology and Cardiovascular Medicine Platelet Aggregation Inhibitors medicine.drug |
| Zdroj: | Journal of cardiovascular pharmacology. 48(2) |
| ISSN: | 0160-2446 |
| Popis: | Up to 20% of serious vascular events in high-risk vascular patients is attributable to a failure of aspirin (ASA) to suppress platelet aggregation. Resveratrol is a cardioprotective phytoestrogen that can inhibit platelet aggregation in animal models. We hypothesized that resveratrol can also inhibit aggregation of platelets from ASA-resistant (ASA-R) patients. Thus, platelet-rich plasma was isolated from ASA-sensitive (ASA-S) and ASA-R patients (aspirin resistance was defined as higher-than-expected aggregation to collagen and epinephrine [>/=40%] after oral treatment with 100 mg/d ASA). Aggregation to adenosine diphosphate (ADP; 5 and 10 mumol/L), collagen (2 mug/mL), and epinephrine (10 mumol/L) in the absence and presence of resveratrol (10 mol/L) was measured by optical aggregometry. Maximal aggregation to 5 mumol/L ADP was only slightly affected by resveratrol. Similar results were obtained using 10 mumol/L ADP. Maximal aggregation of ASA-R platelets to collagen was significantly decreased by resveratrol, whereas resveratrol had only marginal effects in ASA-S platelets. Similar results were obtained with epinephrine as well. Collectively, resveratrol effectively inhibited collagen- and epinephrine-induced aggregation of platelets from ASA-R patients, which may contribute to its cardioprotective effects in high-risk cardiac patients. |
| Databáze: | OpenAIRE |
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