Autophagic degradation of lamins facilitates the nuclear egress of herpes simplex virus type 1
| Autor: | Holger Jastrow, Beate Sodeik, Christiane Silke Heilingloh, Katinka Döhner, Aykut Turan, Alexandra Düthorn, Mirko Kummer, Sylvia Voortmann, Christina Drassner, Niels Schaft, Alexander Steinkasserer, Petra Mühl-Zürbes, Jan Dörrie, Mike Hasenberg, Adalbert Krawczyk, Max E. Kraner, Linda Grosche |
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| Rok vydání: | 2018 |
| Předmět: |
viruses
Medizin Kinesins Herpesvirus 1 Human Biology medicine.disease_cause Virus 03 medical and health sciences Capsid Cytosol 0302 clinical medicine Immune system Commentaries medicine Humans Spotlight Virus Release 030304 developmental biology Cell Nucleus 0303 health sciences Catabolism Autophagy Dendritic Cells Cell Biology Lamins Cell biology Herpes simplex virus Proteolysis 030217 neurology & neurosurgery Lamin |
| Zdroj: | The Journal of Cell Biology |
| ISSN: | 1540-8140 0021-9525 |
| DOI: | 10.1083/jcb.201801151 |
| Popis: | Florence Niedergang introduces work by Turan et al. demonstrating that herpes virus egress from dendritic cells is differentially regulated by kinesin-dependent positioning of lysosomes and autophagic degradation of nuclear lamins. Herpes simplex viruses bud into the nuclear membrane of infected cells. Turan et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201801151) demonstrate that mature dendritic cells control the peripheral location of lysosomes, reducing autophagic degradation of lamins and inhibiting viral release. |
| Databáze: | OpenAIRE |
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