Seroprevalence of pertussis in Madagascar and implications for vaccination
| Autor: | Sandratana Jonhson Raharinantoanina, Richter Razafindratsimandresy, Forrest K. Jones, Lala Rafetrarivony, Solohery Lalaina Razafimahatratra, C. J.E. Metcalf, Jean-Marc Collard, Amy Wesolowski, Simon Cauchemez, Jean-Michel Heraud, Aina Harimanana |
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| Přispěvatelé: | Experimental Bacteriology Laboratory [Antananarivo ], Institut Pasteur de Madagascar, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Johns Hopkins Bloomberg School of Public Health [Baltimore], Johns Hopkins University (JHU), Unité de Virologie [Antananarivo, Madagascar] (IPM), Modélisation mathématique des maladies infectieuses - Mathematical modelling of Infectious Diseases, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Unité d'Epidémiologie [Antananarivo, Madagascar] (IPM), Princeton University, AW and CJEM were supported by the Wellcome Trust (106866/Z/15/Z). AW was also supported by a Career Award at the Scientific Interface by the Burroughs Wellcome Fund., Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Time Factors Epidemiology Whooping Cough serology Serology MESH: Madagascar 0302 clinical medicine Seroepidemiologic Studies [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases Epidemiology and Infection pertussis MESH: Child Medicine 030212 general & internal medicine Child Pertussis Vaccine [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases pertussis Age patterns MESH: Whooping Cough MESH: Infant 3. Good health Vaccination Infectious Diseases Vaccination coverage Child Preschool [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology Adolescent 03 medical and health sciences MESH: Cross-Sectional Studies Environmental health Madagascar Seroprevalence Humans MESH: Adolescent Original Paper MESH: Seroepidemiologic Studies MESH: Humans business.industry MESH: Time Factors MESH: Child Preschool Infant [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry Molecular Biology/Molecular biology MESH: Vaccination vaccination 030104 developmental biology Cross-Sectional Studies MESH: Pertussis Vaccine Infectious disease (medical specialty) [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie Population Risk business |
| Zdroj: | Epidemiology and Infection Epidemiology and Infection, Cambridge University Press (CUP), 2020, 148, pp.e283. ⟨10.1017/S0950268820002800⟩ Epidemiology and Infection, 2020, 148, pp.e283. ⟨10.1017/S0950268820002800⟩ |
| ISSN: | 0950-2688 1469-4409 |
| Popis: | Pertussis is a highly contagious infectious disease and remains an important cause of mortality and morbidity worldwide. Over the last decade, vaccination has greatly reduced the burden of pertussis. Yet, uncertainty in individual vaccination coverage and ineffective case surveillance systems make it difficult to estimate burden and the related quantity of population-level susceptibility, which determines population risk. These issues are more pronounced in low-income settings where coverage is often overestimated, and case numbers are under-reported. Serological data provide a direct characterisation of the landscape of susceptibility to infection; and can be combined with vaccination coverage and basic theory to estimate rates of exposure to natural infection. Here, we analysed cross-sectional data on seropositivity against pertussis to identify spatial and age patterns of susceptibility in children in Madagascar. A large proportion of individuals surveyed were seronegative; however, there were patterns suggestive of natural infection in all the regions analysed. Improvements in vaccination coverage are needed to help prevent additional burden of pertussis in the country. |
| Databáze: | OpenAIRE |
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