De novo expression of MHC class I and class II antigens on endomyocardial biopsies from patients with inflammatory heart disease and rejection following heart transplantation
| Autor: | G. Hufnagel, Axel Haverich, Christian Hengstenberg, Bernhard Maisch, E. G. J. Olsen |
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| Rok vydání: | 1993 |
| Předmět: |
Graft Rejection
Pathology medicine.medical_specialty Myocarditis Helper T lymphocyte Biopsy CD1 Coronary Disease chemical and pharmacologic phenomena Major histocompatibility complex Immune system Antigen MHC class I medicine Humans Pericarditis Cytotoxic T cell biology business.industry Myocardium Histocompatibility Antigens Class I Histocompatibility Antigens Class II medicine.disease Gene Expression Regulation Microscopy Fluorescence Immunology biology.protein Heart Transplantation Cardiology and Cardiovascular Medicine business Endocardium |
| Zdroj: | European Heart Journal. 14:758-763 |
| ISSN: | 1522-9645 0195-668X |
| DOI: | 10.1093/eurheartj/14.6.758 |
| Popis: | Inflammation of the heart muscle is caused either by infection (i.e. coxsackie virus) resulting in myocarditis or by rejection following heart transplantation. These processes induce activation of the immune system. We examined endomyocardial biopsies from patients with myocarditis, perimyocarditis and rejection following heart transplantation and compared these to biopsies from patients with coronary artery disease. The biopsies were examined immunohistologically with specific monoclonal antibodies against class I and class II molecules of the major histocompatibility complex (MHC). MHC class I antigens on the normally negative myocytes were evident in myocarditis (38%) and in rejection after heart transplantation (68%). In the interstitium there was an increase of both MHC class I and class II antigens. MHC class II antigens, however, were never seen on myocytes. MHC class I antigens are required for the action of CD 8 positive cytotoxic T cells. Therefore myocytes which express MHC class I antigens are susceptible to cytotoxic effects of the immune system. MHC class II antigens are essential to T helper cells. By cytokine release, activated T helper cells play a central role in the initiation, regulation and mediation of an immune response in myocarditis and rejection following heart transplantation. |
| Databáze: | OpenAIRE |
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