Obesity-related metabolic and reproductive dysfunction: variations between the sexes
| Autor: | Georgios Dimitriadis, Thomas M. Barber |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
030219 obstetrics & reproductive medicine Endocrinology Diabetes and Metabolism Common Obesity Physiology Adipose tissue 030209 endocrinology & metabolism Biology medicine.disease Obesity Polycystic ovary Sexual dimorphism 03 medical and health sciences 0302 clinical medicine Endocrinology Internal medicine medicine Hormone |
| Zdroj: | Expert review of endocrinologymetabolism. 11(5) |
| ISSN: | 1744-8417 |
| Popis: | Obesity prevalence remains at epidemic levels globally and is showing no signs of abating in either adult or child populations. Areas covered: Obesity-associated metabolic and reproductive diseases appear to be sexually dimorphic. Polycystic Ovary Syndrome (PCOS) and male obesity-associated secondary (hypogonadotrophic) hypogonadism (MOSH) represent two of the most common obesity associated endocrinopathies with sex-specific metabo-reproductive aberrations. These two diseases have entirely separate pathogeneses, with characteristic sex-specific clinico-pathological findings. These differences result from effects of sex-specific hormones, including estrogens and androgens. Such differences in sex-hormones also influence patterns of body-fat distribution. Expert commentary: This article focuses on sex-specific obesity-related metabolic and reproductive dysfunction. To illustrate key sex-related differences in the mechanisms by which obesity contributes towards metabolic and reproductive dysfunction, two common obesity-related conditions affecting women and men are considered: respectively, Polycystic Ovary Syndrome (PCOS) and Male Obesity-associated Secondary Hypogonadism (MOSH). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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