Life-cycle differentiation in Trypanosoma brucei: molecules and mutants
| Autor: | M. Timms, Edward F. Hendriks, F. J. van Deursen, Keith R. Matthews, Mitali Sarkar, J. Wilson |
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| Rok vydání: | 2000 |
| Předmět: |
Genetics
Regulation of gene expression Mutation medicine.medical_specialty biology Genes Protozoan Trypanosoma brucei brucei Mutant Cell Differentiation Trypanosoma brucei biology.organism_classification medicine.disease_cause Biochemistry Genome Cell biology Transformation (genetics) Gene Expression Regulation Molecular genetics medicine Animals Genome Protozoan Gene |
| Zdroj: | Biochemical Society Transactions. 28:531-536 |
| ISSN: | 1470-8752 0300-5127 |
| Popis: | Differentiation between bloodstream and tsetse midgut procyclic forms during the life cycle of the African trypanosome is an attractive model for the analysis of stage-regulated events. In particular, this transformation occurs synchronously, there are well-defined markers for stage-regulated processes and cell lines with specific defects in differentiation have been identified. This combination of tools, combined with the developing Trypanosoma brucei genome database is allowing its underlying controls to be investigated at the molecular and cytological levels. This paper examines some recent discoveries that illuminate some of the key events during trypanosome life-cycle progression. |
| Databáze: | OpenAIRE |
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