New insights into the metal-induced oxidative degradation pathways of transthyretin
| Autor: | Jacob W. McCabe, David H. Russell, Zahra Moghadamchargari, Arthur Laganowsky, Mehdi Shirzadeh, Michael L. Poltash |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
biology
Oxidative degradation 010405 organic chemistry Chemistry Disease progression Metals and Alloys nutritional and metabolic diseases General Chemistry 010402 general chemistry 01 natural sciences Oligomer Article Catalysis 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials Metal Transthyretin chemistry.chemical_compound visual_art Materials Chemistry Ceramics and Composites biology.protein visual_art.visual_art_medium Biophysics |
| Zdroj: | Chemical Communications. 55:4091-4094 |
| ISSN: | 1364-548X 1359-7345 |
| Popis: | The amyloidogenic mechanism of transthyretin is still debated but understanding it fully could lend insight into disease progression and potential therapeutics. Transthyretin was investigated revealing a metal-induced (Cr/Cu) oxidation pathway leading to N-terminal backbone fragmentation and oligomer formation; previously hidden details were revealed only by FT-IM-Orbitrap MS and surface-induced dissociation. |
| Databáze: | OpenAIRE |
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