Circulating miRNA 27a and miRNA150-5p; a noninvasive approach to endometrial carcinoma

Autor:	Eman Ahmed El-Attar, Ziad Abouzeid, Rasha Abdelmawla Ghazala
Rok vydání:	2021
Předmět:	Adult 0301 basic medicine Circulating mirnas Oncology medicine.medical_specialty medicine.medical_treatment Gene Expression Real-Time Polymerase Chain Reaction 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests Internal medicine Positive predicative value microRNA Biomarkers Tumor Genetics Carcinoma Humans Medicine Circulating MicroRNA Epigenetics Molecular Biology Aged Hysterectomy Reverse Transcriptase Polymerase Chain Reaction business.industry Endometrial cancer General Medicine Middle Aged medicine.disease Endometrial Neoplasms Gene Expression Regulation Neoplastic Reverse transcription polymerase chain reaction MicroRNAs 030104 developmental biology Area Under Curve CA-125 Antigen Case-Control Studies 030220 oncology & carcinogenesis Female business
Zdroj:	Molecular Biology Reports.
ISSN:	1573-4978 0301-4851
DOI:	10.1007/s11033-021-06450-6
Popis:	Background The search for novel non-invasive biomarkers such as epigenetic molecular markers is new hope for common & burdensome cancers. We aim to assess serum expression of miRNA 27a and miRNA150-5p in endometrial cancer patients. Methods Serum was drawn for 36 un-intervened endometrial cancer patients scheduled for hysterectomy & 35 controls. miRNA 27a and miRNA150-5p were measured by real time reverse transcription polymerase chain reaction. Results Significant overexpression of both miRNA in patients (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97750c4829f79afc137632caed5ea17a https://doi.org/10.1007/s11033-021-06450-6 Zobrazit plný text záznamu Full text from SpringerLink