Recent Advances in Phenolic Metabolites and Skin Cancer
| Autor: | Zorita Diaconeasa, Teodora Daria Pop |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Skin Neoplasms
medicine.medical_treatment Anti-Inflammatory Agents Apoptosis Review Antioxidants Targeted therapy Mice chemoprevention Neoplasm Metastasis Biology (General) Spectroscopy Skin skin cancer Melanoma Cell Cycle food and beverages General Medicine Computer Science Applications Chemistry medicine.anatomical_structure Immunotherapy Immunosuppressive Agents Ultraviolet Rays QH301-705.5 Catalysis Inorganic Chemistry Phenols Dermis Autophagy medicine melanoma Animals Anticarcinogenic Agents Humans Physical and Theoretical Chemistry Molecular Biology QD1-999 polyphenols Cell Proliferation Chemotherapy Phenol Tea business.industry Organic Chemistry Cancer medicine.disease Radiation therapy Cancer research Skin cancer business |
| Zdroj: | International Journal of Molecular Sciences, Vol 22, Iss 9707, p 9707 (2021) International Journal of Molecular Sciences |
| ISSN: | 1661-6596 1422-0067 |
| Popis: | Skin cancer represents any tumor development from the cutaneous structures within the epidermis, dermis or subcutaneous tissue, and is considered to be the most prevalent type of cancer. Compared to other types of cancer, skin cancer is proven to have a positive growth rate of prevalence and mortality. There are available various treatments, including chemotherapy, immunotherapy, radiotherapy and targeted therapy, but because of the multidrug resistance development, a low success has been registered. By this, the importance of studying naturally occurring compounds that are both safe and effective in the chemoprevention of skin cancer is emphasized. This review focuses on melanoma because it is the deadliest form of skin cancer, with a significantly increasing incidence in the last decades. As chemopreventive agents, we present polyphenols and their antioxidant activity, anti-inflammatory effect, their ability to balance the cell cycle and to induce apoptosis and their various other effects on skin melanoma. Besides chemoprevention, studies suggest that polyphenols can have treating abilities in some conditions. The limitations of using polyphenols are also pointed out, which are related to their poor bioavailability and stability, but as the technology is well developed, it is possible to augment the efficacy of polyphenols in the case of melanoma. |
| Databáze: | OpenAIRE |
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