The effects of stress on dna repair capacity

Autor:	Michael J Forlenza, Andrew Baum, Jean Johanna Latimer
Rok vydání:	2000
Předmět:	DNA repair DNA damage Period (gene) Public Health Environmental and Occupational Health Cancer Endogeny General Medicine General Chemistry medicine.disease Article Andrology Stress (mechanics) chemistry.chemical_compound chemistry medicine Psychology Applied Psychology DNA Nucleotide excision repair
Zdroj:	Psychology & Health. 15:881-891
ISSN:	1476-8321 0887-0446
DOI:	10.1080/08870440008405589
Popis:	Research has shown that lymphocytes of high-distress patients have reduced DNA repair relative to that of low-distress patients and healthy controls. Furthermore, deficits in repair are associated with an increased risk of cancer. Using and academic stress model, we hypothesized that students would exhibit lower levels of Nucleotide Excision Repair (NER) during a stressful exam period when compared to a lower stress period. Participants were 19 healthy graduate level students. NER was measured in lymphocytes using the unscheduled DNA synthesis (UDS) assay with slide autoradiography. Contrary to prediction, mean values for NER significantly increased during the higher stress period relative to the lower stress period controlling for background differences in repair. Furthermore, lymphocytes had significantly increased repair of endogenous damage during the higher stress period. Stress appears to directly increase DNA repair. Additionally, stress may increase DNA repair indirectly by increasing damage to DNA.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::977265336d75e5922c7c274c4595856f https://doi.org/10.1080/08870440008405589 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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