Exclusive Enteral Nutrition : Clinical Effects and Changes in Mucosal Cytokine Profile in Pediatric New Inflammatory Bowel Disease
| Autor: | Ulrika L. Fagerberg, Kerstin Jönsson-Videsäter, Michael Eberhardson, Yigael Finkel, Helena Rolandsdotter |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Adolescent Cytokine profile medicine.medical_treatment IBD Colonoscopy lcsh:TX341-641 Disease Gastroenterology and Hepatology Polymerase Chain Reaction Gastroenterology Inflammatory bowel disease Article Proinflammatory cytokine mucosal cytokines 03 medical and health sciences Enteral Nutrition 0302 clinical medicine remission Crohn Disease children Internal medicine medicine Gastroenterologi Humans Intestinal Mucosa Child 030109 nutrition & dietetics Nutrition and Dietetics medicine.diagnostic_test business.industry exclusive enteral nutrition Interleukin Inflammatory Bowel Diseases medicine.disease digestive system diseases Treatment Outcome Cytokine Parenteral nutrition Cytokines Female 030211 gastroenterology & hepatology business lcsh:Nutrition. Foods and food supply Food Science |
| Zdroj: | Nutrients Volume 11 Issue 2 Nutrients, Vol 11, Iss 2, p 414 (2019) |
| Popis: | Exclusive Enteral Nutrition (EEN) is the first-line treatment in children with Crohn&rsquo s disease (CD) for induction of remission. However, the mode of action remains conjectural. The aim of this study was to investigate whether the effect of EEN is paralleled by changes in the mucosal cytokine profiles (MCP). Twelve children with new onset inflammatory bowel disease (IBD) received induction treatment with a polymeric EEN. We assessed clinical, endoscopic and histologic scoring before and after EEN. Twelve colonic cytokines were analyzed by Polymerase Chain Reaction (PCR) in six of the IBD patients at onset and after EEN as well as in six non-IBD control children at the diagnostic colonoscopy. Twelve children completed 6 weeks of EEN, except from one child who completed 4 weeks. At the control colonoscopy, 83% were in complete clinical remission. Changes were found in the MCPs of individual patients after EEN. In particular, children with IBD showed significantly higher values of Interleukin (IL)-12&beta (p = 0.008) and IL-23&alpha (p = 0.02) compared to non-IBD controls at the diagnostic colonoscopy. Furthermore, an overall change in proinflammatory cytokines was noted in the IBD-group after treatment. Further studies are warranted to understand the role of EEN in MCP. |
| Databáze: | OpenAIRE |
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