Cohesive cancer invasion of the biophysical barrier of smooth muscle
| Autor: | Daniel Hernandez-Cortes, Joe G.N. Garcia, Anne E. Cress, Raymond B. Nagle, William L. Harryman, Kendra D. Marr |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Damp Cancer Research Nicotinamide phosphoribosyltransferase Adipose tissue Biology Article Metastasis Extracellular matrix 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Prostate Neoplasms medicine Extracellular Humans Neoplasm Invasiveness Cancer Muscle Smooth medicine.disease Extracellular Matrix Cell biology 030104 developmental biology medicine.anatomical_structure Oncology chemistry 030220 oncology & carcinogenesis |
| Zdroj: | Cancer Metastasis Rev |
| ISSN: | 1573-7233 0167-7659 |
| DOI: | 10.1007/s10555-020-09950-2 |
| Popis: | Smooth muscle is found around organs in the digestive, respiratory, and reproductive tracts. Cancers arising in the bladder, prostate, stomach, colon, and other sites progress from low-risk disease to high-risk, lethal metastatic disease characterized by tumor invasion into, within, and through the biophysical barrier of smooth muscle. We consider here the unique biophysical properties of smooth muscle and how cohesive clusters of tumor use mechanosensing cell–cell and cell–ECM (extracellular matrix) adhesion receptors to move through a structured muscle and withstand the biophysical forces to reach distant sites. Understanding integrated mechanosensing features within tumor cluster and smooth muscle and potential triggers within adjacent adipose tissue, such as the unique damage-associated molecular pattern protein (DAMP), eNAMPT (extracellular nicotinamide phosphoribosyltransferase), or visfatin, offers an opportunity to prevent the first steps of invasion and metastasis through the structured muscle. |
| Databáze: | OpenAIRE |
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