Complex Exercise Improves Anti-Inflammatory and Anabolic Effects in Osteoarthritis-Induced Sarcopenia in Elderly Women
| Autor: | Jong-Jin Bae, Jung-Chul Lee, Jae-Yong Park |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
WOMAC Activities of daily living Anabolism Leadership and Management medicine.drug_class 030209 endocrinology & metabolism Health Informatics Myostatin Osteoarthritis complex exercise myokine Anti-inflammatory Article sarcopenia 03 medical and health sciences 0302 clinical medicine Health Information Management Internal medicine Myokine medicine biology business.industry Health Policy medicine.disease osteoarthritis Sarcopenia biology.protein Medicine business human activities 030217 neurology & neurosurgery TCSA |
| Zdroj: | Healthcare, Vol 9, Iss 711, p 711 (2021) Healthcare Volume 9 Issue 6 |
| ISSN: | 2227-9032 |
| Popis: | We investigated the effects of a 15-week complex exercise program on osteoarthritis and sarcopenia by analyzing anabolic effects and the impact on the activities of daily living (ADLs). Nineteen women aged ≥60 years with sarcopenia (SEG, n = 9) or diagnosed with osteoarthritis with sarcopenia (OSEG, n = 10) were enrolled and underwent an exercise program. Insulin-like growth factor 1 (IGF-1), irisin, myostatin, interleukin-10 (IL-10), and tumor necrosis factor alpha (TNF-a) levels were analyzed pre- and post-intervention. Thigh cross-sectional area (TCSA) was measured pre- and post-intervention via computed tomography. Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Short Physical Performance Battery (SPBB) were assessed pre- and post-interventions to assess ADL. There was a significant interaction effect between SEG and OSEG at the IGF-1 level post-intervention. Irisin increased and myostatin decreased post-intervention in both groups. IL-10 increased and TNF-α decreased post-intervention with a significant interaction effect in the OSEG group. TCSAs increased post-intervention in both groups. There was a significant interaction between the two groups. OSEG showed a greater WOMAC decrease and SPPB increase post-intervention, and there was a significant interaction effect. Combined exercise may be effective in improving biochemical factors, anabolic effects, and ADL in elderly women with osteoarthritis and sarcopenia. |
| Databáze: | OpenAIRE |
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