Changes in rat brain muscarinic receptors after inhibitory avoidance learning
| Autor: | Arturo Ortega, V. Aleman, Roberto A. Prado-Alcalá, M. A. Diaz Del Guante |
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| Rok vydání: | 1996 |
| Předmět: |
Male
medicine.medical_specialty Scopolamine Derivatives Inhibitory postsynaptic potential Hippocampus General Biochemistry Genetics and Molecular Biology Discrimination Psychological Memory Postsynaptic potential Internal medicine Muscarinic acetylcholine receptor Muscarinic acetylcholine receptor M5 Avoidance Learning Muscarinic acetylcholine receptor M4 medicine Animals Rats Wistar General Pharmacology Toxicology and Pharmaceutics Cerebral Cortex Oxotremorine Brain Muscarinic acetylcholine receptor M3 Muscarinic acetylcholine receptor M2 Pirenzepine General Medicine Muscarinic acetylcholine receptor M1 N-Methylscopolamine Amygdala Receptors Muscarinic Rats Neostriatum Kinetics Endocrinology nervous system Organ Specificity Reinforcement Psychology Neuroscience |
| Zdroj: | Life Sciences. 58:799-809 |
| ISSN: | 0024-3205 |
| Popis: | It is widely accepted that cerebral acetylcholine is necessary for learning and memory, but little is known about the type of muscarinic receptors involved in these functions. To investigate this problem, [3H]-N-methyl-scopolamine which binds to different types of muscarinic receptors, [3H]-Pirenzepine an M1 receptor antagonist, and [3H]-Oxotremorine-M which binds mainly to M2 receptors, were used as ligands to look for possible changes in muscarinic receptor density in neostriatum (NEO), hippocampus (HIP), amygdala (AMY), and temporo-parietal neocortex (CTX), after testing for retention of inhibitory avoidance, trained with high or low footshock intensities. After low reinforcement there was an M1 postsynaptic receptor up-regulation in NEO, HIP, and CTX, and an M2 presynaptic receptor down-regulation in HIP, which suggests a concerted pre- and postsynaptic cholinergic activation in this area. An up-regulation of both M1 and M2 receptors was detected in CTX of low and high footshocked animals, which indicates the presence of a cortical postsynaptic M2 receptor. |
| Databáze: | OpenAIRE |
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