| Autor: |
Yu Sato, Andrew S.P. Sharp, Felix Mahfoud, Stefan Tunev, Ashley Forster, Matthew Ellis, Ana Gomez, Roma Dhingra, Jeremy Ullman, Markus Schlaich, David Lee, Julie Trudel, Douglas A. Hettrick, David E. Kandzari, Renu Virmani, Aloke V. Finn |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology. |
| ISSN: |
1969-6213 |
| Popis: |
Preclinical models have provided key insights into the response of local tissues to radiofrequency (RF) renal denervation (RDN) that is unobtainable from human studies. However, the anatomic translatability of these models to the procedure in humans is incompletely understood. Aims: We aimed to compare the renal arterial anatomy in normotensive pigs treated with RF-RDN to that of human cadavers to evaluate the suitability of normotensive pigs for determining the safety of RF-RDN.Histopathologic analyses were performed on RF-treated renal arteries in a porcine model and untreated control renal arteries. Similar analyses were performed on untreated renal arteries from human cadavers. Results: In both human and porcine renal arteries, the median number of nerves was lower in the more distal sections (the numbers in the proximal, middle, distal, 1The distribution of nerve tissue and the relative distribution of extravascular anatomic structures along the renal artery was similar between humans and pigs, which validates the translational value of the normotensive porcine model for RDN. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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