Methanolic extract of Cucumis melo attenuates ethylene glycol-induced nephrolithiasis in Wistar rats
| Autor: | Dhaval M Patel, Riddhi Trivedi, Anwarulabedin Mohsin Quazi, Sami I. Alzarea, Advaita B Patel, Khalid Saad Alharbi, Ameeduzzafar Zafar, Fahad A. Al-Abaasi, Muhammad Afzal, Imran Kazmi |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Ethylene Glycol
Ethylene Clinical chemistry Urology 030232 urology & nephrology Calcium oxalate chemistry.chemical_element Calcium Pharmacology Nephrolithiasis Oxalate 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Urinary excretion Cucumis melo Animals Rats Wistar biology Plant Extracts Methanol biology.organism_classification Rats chemistry Cucumis Ethylene glycol Phytotherapy |
| Zdroj: | Urolithiasis. 49:301-308 |
| ISSN: | 2194-7236 2194-7228 |
| DOI: | 10.1007/s00240-021-01263-5 |
| Popis: | Evaluation of the effects of methanolic extract of Cucumis melo in ethylene glycol-induced nephrolithiasis on Wistar rats. 0.75% solution of ethylene glycol (EG) in payable water was given to produce nephrolithiasis on Wistar rats. The action of oral intake of methanolic extract of Cucumis melo seed in nephrolithiasis is studied and is matched with the action of oral intake of Cystone (standard) on Wistar rats. EG resulted in hyperoxaluria and deposition of calcium oxalate as well as raised urinary excretion of oxalate and calcium. Supplementation with methanolic extract of Cucumis melo seed decreased the increased renal oxalate, indicating a regulatory effect on oxalate formation endogenously. The outcomes stipulate that the seed of Cucumis melo is endowed with antinephrolithiatic action. |
| Databáze: | OpenAIRE |
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