Influence of IL-6, IL-8, and TGF-β1 gene polymorphisms on the risk of human papillomavirus-infection in women from Pernambuco, Brazil
| Autor: | Maria de Mascena Diniz Maia, Sergio Crovella, Sérgio Ferreira de Lima Júnior, Mayara Mansur Fernandes Tavares, Sandra de Andrade Heráclio, Ronald Moura, Paulo Roberto Eleutério de Souza, Jamilly Lopes de Macêdo, Renata Santos de Oliveira |
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| Přispěvatelé: | Lima, Sérgio Ferreira de, Tavares, Mayara Mansur Fernande, Macedo, Jamilly Lopes de, Oliveira, Renata Santos de, Heráclio, Sandra de Andrade, Maia, Maria de Mascena Diniz, Souza, Paulo Roberto Eleutério de, Moura, Ronald, Crovella, Sergio |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
lcsh:QR1-502 Uterine Cervical Neoplasms Polymerase Chain Reaction lcsh:Microbiology polymorphism 0302 clinical medicine Gene Frequency polymorphisms cytokine host genome HPV Genotype Sanger sequencing HPV infection Articles Middle Aged 030220 oncology & carcinogenesis symbols Female Sample collection Brazil Adult Microbiology (medical) lcsh:Arctic medicine. Tropical medicine Adolescent lcsh:RC955-962 Biology Polymorphism Single Nucleotide Virus Transforming Growth Factor beta1 Young Adult 03 medical and health sciences symbols.namesake Immune system medicine Humans Genetic Predisposition to Disease Allele Interleukin 6 Alleles Aged Base Sequence Interleukin-6 Interleukin-8 Papillomavirus Infections Uterine Cervical Dysplasia medicine.disease Virology Cross-Sectional Studies 030104 developmental biology DNA Viral biology.protein |
| Zdroj: | Memórias do Instituto Oswaldo Cruz Memórias do Instituto Oswaldo Cruz., Vol 111, Iss 11, Pp 663-669 Memórias do Instituto Oswaldo Cruz, Volume: 111, Issue: 11, Pages: 663-669, Published: 24 OCT 2016 |
| ISSN: | 1678-8060 0074-0276 |
| DOI: | 10.1590/0074-02760160051 |
| Popis: | Human papillomavirus (HPV) infections are strongly associated with the development of cervical intraepithelial neoplasias and invasive cervical cancer. Polymorphisms in cytokine-encoding genes and behavioural cofactors could play an important role in protecting an individual against viral infections and cancer. Here, we investigated whether IL-6 -174 G>C, IL-8 +396 G>T, and TGF-β1 +869 G>C and +915 G>C polymorphisms were associated with susceptibility to HPV infection in women from north-east (Pernambuco) Brazil. We analysed 108 healthy uninfected women (HC) and 108 HPV-positive women with cervical lesions. Genetic polymorphisms were assessed using Sanger sequencing and polymerase chain reaction-restriction fragment length polymorphism. Comparison of the distribution of the genotypic and allelic frequencies of the IL-18 +396 T>G polymorphism between HPV infected woman an uninfected controls showed that the GG genotype and G allele were both more frequent in the HC group, and were associated with protection from HPV infection (p = 0.0015; OR = 0.29 CI95% = 0.13-0.61; p = 0.0005; OR = 0.45 CI95% 0.29-0.7, respectively). Individuals from the control group could have previously had HPV infection that was spontaneously eliminated; however, it was undetectable at the time of sample collection. Based on our findings, we hypothesize that the IL-8 +396 G>T polymorphism could interfere with susceptibility to HPV infection, by modulating the ability of immune system to fight the virus. |
| Databáze: | OpenAIRE |
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