Pancreatic beta-cells: Role of glycerol and aquaglyceroporin 7
Autor: | Christine Delporte, Jason Perret, Myrna Virreira |
---|---|
Rok vydání: | 2011 |
Předmět: |
Glycerol
medicine.medical_specialty Glucose uptake medicine.medical_treatment Gene Expression Adipose tissue Enteroendocrine cell Carbohydrate metabolism Biology Biochemistry Mice Somatomedins Insulin-Secreting Cells Internal medicine Insulin Secretion Diabetes Mellitus medicine Animals Humans Insulin Glucose homeostasis Secretion Pancreas Mice Knockout Cell Biology Rats Glucose medicine.anatomical_structure Endocrinology Endoderm Aquaglyceroporins Signal Transduction |
Zdroj: | The International Journal of Biochemistry & Cell Biology. 43:10-13 |
ISSN: | 1357-2725 |
Popis: | Pancreatic β-cells originate from gut endoderm during development. Pancreatic endocrine cells represent about 10% of the mature pancreatic cells, and β-cells represent the majority of endocrine cells. β-cells secrete insulin in response to elevation of nutrient concentrations. Insulin maintains glucose homeostasis by stimulating glucose uptake into muscle and adipose tissue. Aquaglyceroporin 7, permeable to water, glycerol and urea, is expressed in pancreatic β-cells and was recently described as being involved in the control of insulin secretion. |
Databáze: | OpenAIRE |
Externí odkaz: |