Translational biomarkers: from discovery and development to clinical practice
| Autor: | Jaya Goyal, Meena Subramanyam |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Drug discovery business.industry MEDLINE Medical practice Disease Computational biology Health outcomes Bioinformatics Translational Research Biomedical Clinical Practice 03 medical and health sciences 030104 developmental biology Models Animal Drug Discovery Animals Humans Molecular Medicine Biomarker (medicine) Medicine Biomarker discovery business Biomarkers |
| Zdroj: | Drug Discovery Today: Technologies. :3-10 |
| ISSN: | 1740-6749 |
| Popis: | The refinement of disease taxonomy utilizing molecular phenotypes has led to significant improvements in the precision of disease diagnosis and customization of treatment options. This has also spurred efforts to identify novel biomarkers to understand the impact of therapeutically altering the underlying molecular network on disease course, and to support decision-making in drug discovery and development. However, gaps in knowledge regarding disease heterogeneity, combined with the inadequacies of surrogate disease model systems, make it challenging to demonstrate the unequivocal association of molecular and physiological biomarkers to disease pathology. This article will discuss the current landscape in biomarker research and highlight strategies being adopted to increase the likelihood of transitioning biomarkers from discovery to medical practice to enable more objective decision making, and to improve health outcome. |
| Databáze: | OpenAIRE |
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