Adrenal malignant melanoma masquerading as a pheochromocytoma in a patient with a history of a multifocal papillary and medullary thyroid carcinoma
| Autor: | Christos Savvidis, Anastasia D Dede, Manouras Andreas, Constantine A. Stratakis, Christina Dikoglou, Paraskevi Xekouki, Sofia Malaktari-Skarantavou, Haridimos Markogiannakis, Maria E. Barmpari |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Calcitonin
Male Pathology medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Biopsy Dopamine Adrenal Gland Neoplasm Adrenal Gland Neoplasms Pheochromocytoma Malignancy Article 030218 nuclear medicine & medical imaging Metastasis Thyroid carcinoma Diagnosis Differential 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests Positron Emission Tomography Computed Tomography medicine Carcinoma Biomarkers Tumor Humans Thyroid Neoplasms Melanoma business.industry Adrenalectomy General Medicine Middle Aged medicine.disease Immunohistochemistry Carcinoma Papillary Carcinoma Neuroendocrine Treatment Outcome Thyroid Cancer Papillary 030220 oncology & carcinogenesis Phosphopyruvate Hydratase Differential diagnosis business |
| Zdroj: | Hormones (Athens, Greece). 15(2) |
| ISSN: | 2520-8721 |
| Popis: | OBJECTIVE: Adrenal masses usually represent benign and nonfunctional adrenal adenomas; however, primary or metastatic malignancy should also be considered. Discovery of an adrenal mass needs further evaluation in order to exclude malignancy and hormonal secretion. We present a rare case of a possibly primary adrenal malignant melanoma with imaging and biochemical features of a pheochromocytoma. CASE REPORT: A 61-year-old male farmer was referred for evaluation of a mass in the right supraclavicular region and a left adrenal lesion. The patient had a history of a multifocal papillary and medullary thyroid carcinoma. Laboratory tests revealed increased 24hour urinary dopamine and also increased serum calcitonin and neuron specific enolase. A pathology report of the resected right supraclavicular mass and left adrenal showed a malignant melanoma. CONCLUSION: This is a case of a possibly primary adrenal malignant melanoma with imaging and biochemical features of a pheochromocytoma. Although this case is very rare and there are rigid diagnostic criteria for the diagnosis of primary adrenal melanoma, it underlines the fact that the differential diagnosis of a dopamine secreting adrenal mass should include primary or metastatic malignant melanoma in order to determine the best diagnostic approach for the patient and select the most appropriate surgical management. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink