Changes in N-acetyl-β-glucosaminidase activity in hepatic damage
| Autor: | Hiroshi Abe, Takeo Koizumi, Toshihiko Suematsu, Namio Iwabori |
|---|---|
| Rok vydání: | 1968 |
| Předmět: |
Male
medicine.medical_specialty Glycoside Hydrolases Hydrocortisone Biology Surface-Active Agents N acetyl β glucosaminidase Hepatic damage Internal medicine Freezing medicine Animals Glucosaminidase Vitamin A chemistry.chemical_classification Carbon Tetrachloride Poisoning Chronic hepatic Liver Diseases Adrenalectomy General Medicine Enzyme assay Rats Endocrinology Enzyme Liver Biochemistry chemistry Acute Disease Chronic Disease biology.protein Chemical and Drug Induced Liver Injury Lysosomes Intracellular Particle fraction |
| Zdroj: | Biochimica et Biophysica Acta (BBA) - Enzymology. 151:628-636 |
| ISSN: | 0005-2744 |
| DOI: | 10.1016/0005-2744(68)90009-0 |
| Popis: | In order to elucidate the mechanisms of the elevation of the serum N -acetyl- β -glucosaminidase activity found in hepatic damage, the intracellular distribution pattern of the enzyme in the liver was investigated. 1. 1.In acute hepatic injury, a significant decrease of the enzyme activity was seen in both the lysosomal and supernatant fractions of the liver while in the serum activity increased simultaneously. 2. 2.In chronic hepatic injury, the enzyme activity in the serum and liver supernatant fraction was found to be increased. This effect was more marked with advance of the damage. Changes in the enzyme activity both in the serum and in the supernatant fraction of the liver were seen to be nearly inversely proportional to the change in enzyme activity in the particle fraction of the liver. 3. 3.In the process of convalescing from chronic hepatic injury, the enzyme activity was markedly increased in both the particle and supernatant fractions of the liver. 4. 4.It was found that the release of the enzyme from the particle fraction of the liver occurs under various conditions; this is discussed in relation to the changes in hepatic acid mucoploysaccharides. |
| Databáze: | OpenAIRE |
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