Impact of MnSOD and GPx1 Genotype at Different Levels of Enteral Nutrition Exposure on Oxidative Stress and Mortality: A Post hoc Analysis From the FeDOx Trial
| Autor: | Sally Freels, Alan M. Diamond, Sarah J. Peterson, Omar Lateef, Carol A. Braunschweig, Liam McKeever |
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| Rok vydání: | 2020 |
| Předmět: |
GPX1
medicine.medical_specialty Calorie Genotype 030309 nutrition & dietetics Medicine (miscellaneous) Single-nucleotide polymorphism medicine.disease_cause Article 03 medical and health sciences 0302 clinical medicine Enteral Nutrition Glutathione Peroxidase GPX1 Internal medicine Post-hoc analysis medicine Humans 0303 health sciences Glutathione Peroxidase Nutrition and Dietetics business.industry Superoxide Dismutase Confounding Oxidative Stress Parenteral nutrition 030211 gastroenterology & hepatology business Oxidative stress |
| Zdroj: | JPEN J Parenter Enteral Nutr |
| ISSN: | 1941-2444 |
| Popis: | Background Converting nutrition support to energy results in free radical production from the electron chain transport, possibly increasing oxidative stress. Highly prevalent single nucleotide polymorphisms (SNP) exist for the genes encoding antioxidant enzymes responsible for the detoxification of reactive oxygen species. Objective Our objective was to explore the interaction between nutrition support and genetic polymorphisms for two anti-oxidant proteins (rs4880 SNP for manganese superoxide dismutase and rs1050450 SNP for glutathione peroxidase 1) on oxidative stress and secondarily on ICU mortality. Design We performed a post-hoc analysis on 34 mechanically ventilated sepsis patients from a the FeDOX trial. Participants were dichotomized into those who carried both the rs4880 and the rs1050450 at-risk alleles (Risk Group) versus all others (Non-Risk Group). We explored the interaction between genotype and the percent time spent in the upper median of calorie exposure on oxidative stress and ICU mortality. Results Adjusting for confounders, the slope of log F2-isoprostane levels across percentage of days spent in the upper median of daily kcal/kg was 0.01 higher in the Risk Group compared to the Non-Risk Group (p = 0.01). Every every 1 percent increase in days spent in the upper median of daily Kcals/kg was associated with an adjusted 10.3 percent increased odds of ICU mortality amongst participants in the Risk Group (OR = 1.103, p = 0.06) but was highly insignificant in the Non-Risk group (OR = 0.991, p = 0.79). Conclusions Nutrition support may lead to increased oxidative stress and worse clinical outcomes in a large percent of ICU patients with an at-risk genotype. This article is protected by copyright. All rights reserved. |
| Databáze: | OpenAIRE |
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