Cross‐Reactivity between Immunodominant Human T Lymphotropic Virus Type Itaxand Neurons: Implications for Molecular Mimicry
| Autor: | Yvette Morcos, John N. Brady, John M. Stuart, Sangmin Lee, Michael C. Levin |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
medicine.drug_class
viruses Cross Reactions medicine.disease_cause Monoclonal antibody Immunoglobulin G Epitope immune system diseases hemic and lymphatic diseases Tropical spastic paraparesis medicine Humans Immunology and Allergy health care economics and organizations Ribonucleoprotein Neurons Human T-lymphotropic virus 1 biology Immunodominant Epitopes Molecular Mimicry virus diseases Gene Products tax medicine.disease biology.organism_classification Virology Molecular mimicry Infectious Diseases biology.protein Antibody |
| Zdroj: | The Journal of Infectious Diseases. 186:1514-1517 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1086/344734 |
| Popis: | Human T lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is associated with immunoreactivity to HTLV-I tax. Antibodies isolated from patients with HAM/TSP and monoclonal antibodies (MAbs) to HTLV-I tax stained neurons. In neuronal extracts, HAM/TSP immunoglobulin G identified heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) as the autoantigen. Importantly, tax MAbs reacted with hnRNP A1. To identify the epitope recognized by the tax MAbs, the fine epitope specificity of the antibodies was determined using overlapping peptides. This analysis identified an epitope at the C-terminus (tax(346-353)), which overlaps a human immunodominant domain. Preincubation of this peptide with tax MAbs inhibited antibody binding to tax, hnRNP A1, and neurons. This indicates that a cross-reactive immune response between HTLV-I tax and neuronal hnRNP A1 is contained within the human immunodominant epitope of tax and suggests that molecular mimicry plays a role in the pathogenesis of HAM/TSP. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|