High-sensitivity cardiac troponin T is a biomarker for atherosclerosis in systemic lupus erythematous patients: a cross-sectional controlled study
| Autor: | Marie-Paule Chauveheid, Rachid Abbas, Noémie Chanson, Thomas Papo, Brigitte Escoubet, Antoine Dossier, Monique Dehoux, Camille Chenevier-Gobeaux, Gillian Divard, Karim Sacre |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty lcsh:Diseases of the musculoskeletal system Population Lupus 030204 cardiovascular system & hematology Sensitivity and Specificity Asymptomatic 03 medical and health sciences 0302 clinical medicine Troponin T Risk Factors Internal medicine medicine Humans Lupus Erythematosus Systemic cardiovascular diseases education skin and connective tissue diseases Cause of death 2. Zero hunger 030203 arthritis & rheumatology education.field_of_study Framingham Risk Score business.industry Odds ratio Biomarker Middle Aged Atherosclerosis Plaque Atherosclerotic 3. Good health Cross-Sectional Studies Cardiovascular Diseases Multivariate Analysis Cardiology Biomarker (medicine) Female medicine.symptom lcsh:RC925-935 business Body mass index Biomarkers Research Article |
| Zdroj: | Arthritis Research & Therapy, Vol 19, Iss 1, Pp 1-7 (2017) Arthritis Research & Therapy |
| ISSN: | 1478-6362 |
| DOI: | 10.1186/s13075-017-1352-7 |
| Popis: | Background Cardiovascular disease (CVD) is the main cause of death in systemic lupus erythematous (SLE) patients. The Framingham score underestimates the risk for CVD in this population. Our study aimed to determine whether serum high-sensitivity cardiac troponin T (HS-cTnT) might help to identify SLE patients at risk for CVD. Methods The presence of carotid plaques was prospectively assessed by ultrasound in 63 consecutive SLE patients asymptomatic for CVD and 18 controls. Serum HS-cTnT concentration was measured using the electrochemiluminescence method. Factors associated with carotid plaques were identified and multivariate analysis was performed. Results Framingham score was low in both SLE patients (median 1 (range 1–18%)) and controls (1 (1–13%)). Nevertheless, 23 (36.5%) SLE patients, but only 2 (11.1%) controls (p = 0.039), had carotid plaque detected by vascular ultrasound. In the multivariate analysis, only age (p = 0.006) and SLE status (p = 0.017) were independently associated with carotid plaques. Serum HS-cTnT concentration was detectable (i.e. >3 ng/L) in 37 (58.7%) SLE patients and 6 (33.3%) controls (p = 0.057). Interestingly, 87% of SLE patients with carotid plaques, but only 42.5% of SLE patients without plaques (p |
| Databáze: | OpenAIRE |
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