Assessment of Inorganic Phosphate Intake by the Measurement of the Phosphate/Urea Nitrogen Ratio in Urine
| Autor: | Arnold J. Felsenfeld, María Dolores López-Zamorano, Cristina Membrives-González, Francisco Caravaca, Rafael Santamaria, Noemi Vergara, Eugenio J De la Torre, Sagrario Soriano, Rodrigo López-Baltanás, Mariano Rodriguez, Maria Victoria Pendon-Ruiz de Mier, Cristian Rodelo-Haad, Juan R. Muñoz-Castañeda, Alejandro Martin-Malo |
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| Přispěvatelé: | [Pendón-Ruiz de Mier,MV, Vergara,N, Rodelo-Haad,C, Membrives-González,C, López-Baltanás,R, Muñoz-Castañeda,JR, Martín-Malo,A, Soriano,S, Santamaría,R, Rodríguez,M] Maimonides Institute for Biomedical Research of Cordoba (IMIBIC), Reina Sofia University Hospital, Nephrology Service, University of Cordoba, Cordoba, Spain. [Pendón-Ruiz de Mier,MV, Santamaría,R] Spanish Renal Research Network (REDinREN), Institute of Health Carlos III, Madrid, Spain. [López-Zamorano,MD] Nephrology Service, Reina Sofia University Hospital, Cordoba, Spain. [Muñoz-Castañeda,JR, Rodríguez,M] EUTOXandCKD-MBD groups of the ERA-EDTA, Spanish Renal Research Network (REDinREN), Institute of Health Carlos III, Madrid, Spain. [Caravaca,F] Nephrology Service, Infanta Cristina Hospital, Badajoz, Spain. [Felsenfeld,AJ] Department of Medicine, Veterans Affairs Greater Los Angeles Healthcare System and the David Geffen School of Medicine, University of California, Los Angeles, USA. [De la Torre,EJ] General Medicine, Miguelturra Clinic, Ciudad Real, Spain., This work was supported by a Spanish government grant from the Programa Nacional I+D+I 2013–2016 and Instituto de Salud Carlos III (ISCIII) Grants PI18/0138, PI17/01010 co-financing from European Funds (FEDER), Consejería de Salud and EUTOX and REDinREN from the ISCIII. J.R.M.-C. is senior researcher supported by the Nicolás Monardes Programme, Consejería de Salud-Servicio Andaluz de Salud (Junta de Andalucía). |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Factor de crecimiento fibroblástico 23
Male phosphate intake 030232 urology & nephrology Urine 030204 cardiovascular system & hematology Intestinal absorption Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings] chemistry.chemical_compound Eating 0302 clinical medicine FGF23 Organisms::Eukaryota::Animals [Medical Subject Headings] Urea Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Rats::Rats Wistar [Medical Subject Headings] Insuficiencia renal crónica Persons::Persons::Age Groups::Adult::Aged [Medical Subject Headings] Nutrition and Dietetics Chemicals and Drugs::Organic Chemicals::Urea [Medical Subject Headings] Urea nitrogen Middle Aged Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cross-Sectional Studies [Medical Subject Headings] phosphaturia Hormona paratiroidea Female lcsh:Nutrition. Foods and food supply PTH Adult Hipofosfatemia familiar Urinary system Check Tags::Male [Medical Subject Headings] lcsh:TX341-641 Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Diet [Medical Subject Headings] Article Phosphates 03 medical and health sciences Inorganic phosphate Animal science medicine CKD Animals Humans Rats Wistar Persons::Persons::Age Groups::Adult [Medical Subject Headings] Aged Persons::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings] Chemicals and Drugs::Biological Factors::Intercellular Signaling Peptides and Proteins::Fibroblast Growth Factors [Medical Subject Headings] medicine.disease Phosphate Diet Rats Chemicals and Drugs::Inorganic Chemicals::Acids::Acids Noncarboxylic::Phosphorus Acids::Phosphoric Acids::Phosphates [Medical Subject Headings] Fibroblast Growth Factor-23 Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Rats [Medical Subject Headings] Cross-Sectional Studies chemistry Check Tags::Female [Medical Subject Headings] Metabolic syndrome Food Science Kidney disease |
| Zdroj: | Nutrients Volume 13 Issue 2 Nutrients, Vol 13, Iss 292, p 292 (2021) |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu13020292 |
| Popis: | In chronic kidney disease (CKD) patients, it would be desirable to reduce the intake of inorganic phosphate (P) rather than limit the intake of P contained in proteins. Urinary excretion of P should reflect intestinal absorption of P(inorganic plus protein-derived). The aim of the present study is to determine whether the ratio of urinary P to urinary urea nitrogen (P/UUN ratio) helps identify patients with a high intake of inorganic P.A cross-sectional study was performed in 71 patients affected by metabolic syndrome with CKD (stages 2&ndash 3) with normal serum P concentration. A 3-day dietary survey was performed to estimate the average daily amount and the source of P ingested. The daily intake of P was 1086.5 ± 361.3 mg/day 64% contained in animal proteins, 22% in vegetable proteins, and 14% as inorganic P. The total amount of P ingested did not correlate with daily phosphaturia, but it did correlate with the P/UUN ratio (p < 0.018). Patients with the highest tertile of the P/UUN ratio > 71.1 mg/g presented more abundant inorganic P intake (p < 0.038).The P/UUN ratio is suggested to be a marker of inorganic P intake. This finding might be useful in clinical practices to identify the source of dietary P and to make personalized dietary recommendations directed to reduce inorganic P intake. |
| Databáze: | OpenAIRE |
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